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. 2012 Jul 1;4(3):253-8.
doi: 10.4161/derm.21923.

Hyaluronic acid: A key molecule in skin aging

Eleni Papakonstantinou  1 , Michael Roth, George Karakiulakis
Affiliations

Hyaluronic acid: A key molecule in skin aging

Eleni Papakonstantinou et al. Dermatoendocrinol. .

Abstract

SKIN AGING IS A MULTIFACTORIAL PROCESS CONSISTING OF TWO DISTINCT AND INDEPENDENT MECHANISMS: intrinsic and extrinsic aging. Youthful skin retains its turgor, resilience and pliability, among others, due to its high content of water. Daily external injury, in addition to the normal process of aging, causes loss of moisture. The key molecule involved in skin moisture is hyaluronic acid (HA) that has unique capacity in retaining water. There are multiple sites for the control of HA synthesis, deposition, cell and protein association and degradation, reflecting the complexity of HA metabolism. The enzymes that synthesize or catabolize HA and HA receptors responsible for many of the functions of HA are all multigene families with distinct patterns of tissue expression. Understanding the metabolism of HA in the different layers of the skin and the interactions of HA with other skin components will facilitate the ability to modulate skin moisture in a rational manner.

Keywords: CD44; RHAMM; hyaluronic acid; hyaluronic acid synthases; hyaluronidases; skin aging.

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References

    1. Berneburg M, Trelles M, Friguet B, Ogden S, Esrefoglu M, Kaya G, et al. How best to halt and/or revert UV-induced skin ageing: strategies, facts and fiction. Exp Dermatol. 2008;17:228–40. - PubMed
    1. Makrantonaki E, Adjaye J, Herwig R, Brink TC, Groth D, Hultschig C, et al. Age-specific hormonal decline is accompanied by transcriptional changes in human sebocytes in vitro. Aging Cell. 2006;5:331–44. doi: 10.1111/j.1474-9726.2006.00223.x. - DOI - PubMed
    1. Brincat MP. Hormone replacement therapy and the skin. Maturitas 2000; 35:107–117. 9 Makrantonaki E, Zouboulis CC. Androgens and aging of the skin. Curr Opin Endocrinol Diabetes Obes. 2009;16:240–5. - PubMed
    1. Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 2002;138:1462–70. doi: 10.1001/archderm.138.11.1462. - DOI - PubMed
    1. Chung JH, Kang S, Varani J, Lin J, Fisher GJ, Voorhees JJ. Decreased extracellular-signal-regulated kinase and increased stress-activated MAP kinase activities in aged human skin in vivo. J Invest Dermatol. 2000;115:177–82. doi: 10.1046/j.1523-1747.2000.00009.x. - DOI - PubMed