Vinculin and metavinculin: oligomerization and interactions with F-actin
- PMID: 23466368
- DOI: 10.1016/j.febslet.2013.02.042
Vinculin and metavinculin: oligomerization and interactions with F-actin
Abstract
Vinculin, and its splice variant metavinculin, are scaffolding proteins that localize to cellular adhesions. Vinculin is a key player in mediating cell adhesion, motility, and cellular response to force. In the past decade, a number of new studies have evaluated the importance of vinculin oligomers, especially in their role of bundling F-actin. Emerging evidence also suggests that vinculin oligomerization is important for vinculin's scaffolding function. Here we describe the latest findings on vinculin's interaction with F-actin and we clarify the different known vinculin oligomers. Differences in these functions between vinculin and metavinculin provide key insights to the structure and function of these oligomers, and should guide further studies.
Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Similar articles
-
The Structural Basis of Actin Organization by Vinculin and Metavinculin.J Mol Biol. 2016 Jan 16;428(1):10-25. doi: 10.1016/j.jmb.2015.09.031. Epub 2015 Oct 20. J Mol Biol. 2016. PMID: 26493222 Free PMC article.
-
The C-terminal tail domain of metavinculin, vinculin's splice variant, severs actin filaments.J Cell Biol. 2012 May 28;197(5):585-93. doi: 10.1083/jcb.201111046. Epub 2012 May 21. J Cell Biol. 2012. PMID: 22613835 Free PMC article.
-
The Cryogenic Electron Microscopy Structure of the Cell Adhesion Regulator Metavinculin Reveals an Isoform-Specific Kinked Helix in Its Cytoskeleton Binding Domain.Int J Mol Sci. 2021 Jan 11;22(2):645. doi: 10.3390/ijms22020645. Int J Mol Sci. 2021. PMID: 33440717 Free PMC article.
-
New insights into vinculin function and regulation.Int Rev Cell Mol Biol. 2011;287:191-231. doi: 10.1016/B978-0-12-386043-9.00005-0. Int Rev Cell Mol Biol. 2011. PMID: 21414589 Free PMC article. Review.
-
The role of vinculin in the regulation of the mechanical properties of cells.Cell Biochem Biophys. 2009;53(3):115-26. doi: 10.1007/s12013-009-9047-6. Cell Biochem Biophys. 2009. PMID: 19350419 Review.
Cited by
-
An integrative framework identifies alternative splicing events in colorectal cancer development.Mol Oncol. 2014 Feb;8(1):129-41. doi: 10.1016/j.molonc.2013.10.004. Epub 2013 Oct 19. Mol Oncol. 2014. PMID: 24189147 Free PMC article.
-
Cytotoxicity and Initial Biocompatibility of Endodontic Biomaterials (MTA and Biodentine™) Used as Root-End Filling Materials.Biomed Res Int. 2016;2016:7926961. doi: 10.1155/2016/7926961. Epub 2016 Aug 9. Biomed Res Int. 2016. PMID: 27595108 Free PMC article.
-
The Structural Basis of Actin Organization by Vinculin and Metavinculin.J Mol Biol. 2016 Jan 16;428(1):10-25. doi: 10.1016/j.jmb.2015.09.031. Epub 2015 Oct 20. J Mol Biol. 2016. PMID: 26493222 Free PMC article.
-
Complete Model of Vinculin Suggests the Mechanism of Activation by Helical Super-Bundle Unfurling.Protein J. 2022 Feb;41(1):55-70. doi: 10.1007/s10930-022-10040-1. Epub 2022 Jan 10. Protein J. 2022. PMID: 35006498
-
The PET and LIM1-2 domains of testin contribute to intramolecular and homodimeric interactions.PLoS One. 2017 May 18;12(5):e0177879. doi: 10.1371/journal.pone.0177879. eCollection 2017. PLoS One. 2017. PMID: 28542564 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Miscellaneous
