Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Mar;40(1):109-24.
doi: 10.1016/j.clp.2012.12.008. Epub 2013 Jan 17.

Inflammatory signaling in necrotizing enterocolitis

Isabelle G De Plaen  1
Affiliations
Review

Inflammatory signaling in necrotizing enterocolitis

Isabelle G De Plaen. Clin Perinatol. 2013 Mar.

Abstract

The pathogenesis of necrotizing enterocolitis (NEC) is complex and its speed of progression is variable. To gain understanding of the disease, researchers have examined tissues resected from patients with NEC; however, as these are obtained at late stages of the disease, they do not yield clues about the early pathogenic events leading to NEC. Therefore, animal models are used and have helped identify a role for several mediators of the inflammatory network in NEC. In this article, we discuss the evidence for the role of these inflammatory mediators and conclude with a current unifying hypothesis regarding NEC pathogenesis.

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
Schematic representation of the risk factors of the premature intestine to injury.
Fig. 2
Fig. 2
Signaling events leading to NF-κB activation
Fig. 3
Fig. 3
Pathogenesis of NEC-Current hypothesis.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Wang Y, Hoenig JD, Malin KJ, et al. 16S rRNA gene-based analysis of fecal microbiota from preterm infants with and without necrotizing enterocolitis. The ISME journal. 2009;3:944–954. - PMC - PubMed
    1. Dinsmore JE, Jackson RJ, Smith SD. The protective role of gastric acidity in neonatal bacterial translocation. J Pediatr Surg. 1997;32:1014–1016. - PubMed
    1. Hooper LV, Wong MH, Thelin A, et al. Molecular analysis of commensal host-microbial relationships in the intestine. Science. 2001;291:881–884. - PubMed
    1. Rozenfeld RA, Liu X, DePlaen I, et al. Role of gut flora on intestinal group II phospholipase A2 activity and intestinal injury in shock. Am J Physiol Gastrointest Liver Physiol. 2001;281:G957–G963. - PubMed
    1. Carlisle EM, Poroyko V, Caplan MS, et al. Gram negative bacteria are associated with the early stages of necrotizing enterocolitis. PloS one. 2011;6:e18084. - PMC - PubMed

Substances