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Review
. 2013 Feb 14;494(7436):185-94.
doi: 10.1038/nature11896.

Molecular signatures of G-protein-coupled receptors

A J Venkatakrishnan  1 , Xavier Deupi, Guillaume Lebon, Christopher G Tate, Gebhard F Schertler, M Madan Babu
Affiliations
Review

Molecular signatures of G-protein-coupled receptors

A J Venkatakrishnan et al. Nature. .

Abstract

G-protein-coupled receptors (GPCRs) are physiologically important membrane proteins that sense signalling molecules such as hormones and neurotransmitters, and are the targets of several prescribed drugs. Recent exciting developments are providing unprecedented insights into the structure and function of several medically important GPCRs. Here, through a systematic analysis of high-resolution GPCR structures, we uncover a conserved network of non-covalent contacts that defines the GPCR fold. Furthermore, our comparative analysis reveals characteristic features of ligand binding and conformational changes during receptor activation. A holistic understanding that integrates molecular and systems biology of GPCRs holds promise for new therapeutics and personalized medicine.

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References

    1. Curr Opin Struct Biol. 2009 Aug;19(4):386-95 - PubMed
    1. Nature. 2011 May 18;474(7352):521-5 - PubMed
    1. Protein Eng Des Sel. 2005 Feb;18(2):103-10 - PubMed
    1. Sci Signal. 2011 Aug 9;4(185):ra51 - PubMed
    1. Nature. 2012 Jan 29;482(7384):237-40 - PubMed

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