Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Jan 8;17(1):61-72.
doi: 10.1016/j.cmet.2012.12.010.

Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis

Hoon-Ki Sung  1 , Kyung-Oh Doh, Joe Eun Son, Jin Gyoon Park, Yunui Bae, Soojeong Choi, Seana Mary Lunney Nelson, Rebecca Cowling, Kristina Nagy, Iacovos P Michael, Gou Young Koh, S Lee Adamson, Tony Pawson, Andras Nagy
Affiliations
Free article

Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis

Hoon-Ki Sung et al. Cell Metab. .
Free article

Abstract

Vascular endothelial growth factor A (VEGF) is highly expressed in adipose tissue. Its role, however, has not been fully elucidated. Here, we reveal the metabolic role of adipose-VEGF by studying mice with deletion (VEGF(AdΔ)) or doxycycline-inducible overexpression of a VEGF transgene (VEGF(AdTg)) in the adipose tissue. VEGF(AdΔ) mice have reduced adipose vascular density and show adipose hypoxia, apoptosis, inflammation, and metabolic defects on a high-fat diet. In contrast, induction of VEGF expression in VEGF(AdTg) mice leads to increased adipose vasculature and reduced hypoxia. The latter changes are sufficient to counteract an established compromising effect of high-fat diet on the metabolism, indicating that metabolic misbalance is reversible by adipose vessel density increase. Our data clearly show the essential role of VEGF signaling for adequate adipose function. Besides revealing insights into the molecular mechanisms of obesity-related metabolic diseases, this study points to the therapeutic potential of increased adipose angiogenesis.

PubMed Disclaimer

Comment in

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources