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Review
. 2013:31:259-83.
doi: 10.1146/annurev-immunol-032712-095956. Epub 2013 Jan 3.

Metabolic regulation of T lymphocytes

Nancie J MacIver  1 , Ryan D Michalek, Jeffrey C Rathmell
Affiliations
Review

Metabolic regulation of T lymphocytes

Nancie J MacIver et al. Annu Rev Immunol. 2013.

Abstract

T cell activation leads to dramatic shifts in cell metabolism to protect against pathogens and to orchestrate the action of other immune cells. Quiescent T cells require predominantly ATP-generating processes, whereas proliferating effector T cells require high metabolic flux through growth-promoting pathways. Further, functionally distinct T cell subsets require distinct energetic and biosynthetic pathways to support their specific functional needs. Pathways that control immune cell function and metabolism are intimately linked, and changes in cell metabolism at both the cell and system levels have been shown to enhance or suppress specific T cell functions. As a result of these findings, cell metabolism is now appreciated as a key regulator of T cell function specification and fate. This review discusses the role of cellular metabolism in T cell development, activation, differentiation, and function to highlight the clinical relevance and opportunities for therapeutic interventions that may be used to disrupt immune pathogenesis.

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Figures

Figure 1
Figure 1
T cell metabolic programs match functional demands. Resting T cells oxidize glucose-derived pyruvate, along with lipids and amino acids, to efficiently produce ATP/energy required for immune surveillance. Upon activation, lipid oxidation is downregulated, and glycolysis increases along with glutamine oxidation, in order to produce biosynthetic precursors required for rapid cell growth and proliferation. At the end of an immune response, the cells that survive to become memory T cells revert back to lipid oxidation with increased capacity for efficient energy generation.
Figure 2
Figure 2
Specific T cell lineages possess unique metabolic profiles that are essential for their function and maintenance. The predominant metabolic program and key regulators are highlighted for each of the T cell subtypes shown here.
See this image and copyright information in PMC

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References

    1. Warburg O. On the origin of cancer cells. Science. 1956;123:309–14. - PubMed
    1. Koppenol WH, Bounds PL, Dang CV. Otto Warburg's contributions to current concepts of cancer metabolism. Nat. Rev. Cancer. 2011;11:325–37. - PubMed
    1. Warburg O, Gawehn K, Geissler AW. Metabolism of leukocytes. Z. Naturforsch. B. 1958;13B:515–16. (In German) - PubMed
    1. Swainson L, Kinet S, Manel N, Battini JL, Sitbon M, Taylor N. Glucose transporter 1 expression identifies a population of cycling CD4+ CD8+ human thymocytes with high CXCR4-induced chemotaxis. Proc. Natl. Acad. Sci. USA. 2005;102:12867–72. - PMC - PubMed
    1. Yu Q, Erman B, Bhandoola A, Sharrow SO, Singer A. In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells. J. Exp. Med. 2003;197:475–87. - PMC - PubMed

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