Stereotyped B cell receptors in B cell leukemias and lymphomas
- PMID: 23296962
- DOI: 10.1007/978-1-62703-269-8_8
Stereotyped B cell receptors in B cell leukemias and lymphomas
Abstract
Recent research has revealed the existence of subsets (clusters) of patients with different types of B-cell lymphomas and leukemias with restricted, "stereotyped" immunoglobulin (IG) variable heavy complementarity-determining region 3 (VH CDR3) sequences within their B cell receptors (BcR), suggesting selection by common epitopes or classes of structurally similar epitopes. BcR stereotypy was initially described in chronic lymphocytic leukemia (CLL), where it constitutes a remarkably frequent feature of the IG repertoire, and subsequently identified in other malignancies, including mantle cell lymphoma and splenic marginal-zone lymphoma. Of note, at least in CLL, emerging evidence indicates that the grouping of cases into distinct clusters with stereotyped BcR is functionally and prognostically relevant. Hence, the reliable identification of BcR stereotypy may assist in the investigation of the nature of the selecting antigens and immune pathways leading to lymphoma development, and also potentially pave the way for tailored treatment strategies applicable to each major stereotyped subset. In this chapter, we provide an overview of BcR stereotypy in human B-cell malignancies, and outline previous and current methodological approaches used for its identification.
Similar articles
-
Stereotyped B Cell Receptor Immunoglobulins in B Cell Lymphomas.Methods Mol Biol. 2019;1956:139-155. doi: 10.1007/978-1-4939-9151-8_7. Methods Mol Biol. 2019. PMID: 30779034 Review.
-
Stereotyped B-Cell Receptor Immunoglobulins in B-Cell Lymphomas.Methods Mol Biol. 2025;2865:125-143. doi: 10.1007/978-1-0716-4188-0_6. Methods Mol Biol. 2025. PMID: 39424723
-
The significance of stereotyped B-cell receptors in chronic lymphocytic leukemia.Hematol Oncol Clin North Am. 2013 Apr;27(2):237-50. doi: 10.1016/j.hoc.2012.12.001. Hematol Oncol Clin North Am. 2013. PMID: 23561471 Review.
-
A different ontogenesis for chronic lymphocytic leukemia cases carrying stereotyped antigen receptors: molecular and computational evidence.Leukemia. 2010 Jan;24(1):125-32. doi: 10.1038/leu.2009.186. Epub 2009 Sep 17. Leukemia. 2010. PMID: 19759557
-
Exploiting B-cell Receptor Stereotypy to Design Tailored Immunotherapy in Chronic Lymphocytic Leukemia.Clin Cancer Res. 2021 Feb 1;27(3):729-739. doi: 10.1158/1078-0432.CCR-20-1632. Epub 2020 Oct 13. Clin Cancer Res. 2021. PMID: 33051305
Cited by
-
The promise and challenge of high-throughput sequencing of the antibody repertoire.Nat Biotechnol. 2014 Feb;32(2):158-68. doi: 10.1038/nbt.2782. Epub 2014 Jan 19. Nat Biotechnol. 2014. PMID: 24441474 Free PMC article. Review.
-
Restricted, canonical, stereotyped and convergent immunoglobulin responses.Philos Trans R Soc Lond B Biol Sci. 2015 Sep 5;370(1676):20140238. doi: 10.1098/rstb.2014.0238. Philos Trans R Soc Lond B Biol Sci. 2015. PMID: 26194752 Free PMC article. Review.
-
B cell receptor isotypes differentially associate with cell signaling, kinetics, and outcome in chronic lymphocytic leukemia.J Clin Invest. 2022 Jan 18;132(2):e149308. doi: 10.1172/JCI149308. J Clin Invest. 2022. PMID: 34813501 Free PMC article.
-
Clustering based approach for population level identification of condition-associated T-cell receptor β-chain CDR3 sequences.BMC Bioinformatics. 2021 Mar 25;22(1):159. doi: 10.1186/s12859-021-04087-7. BMC Bioinformatics. 2021. PMID: 33765908 Free PMC article.
-
An EBNA3C-deleted Epstein-Barr virus (EBV) mutant causes B-cell lymphomas with delayed onset in a cord blood-humanized mouse model.PLoS Pathog. 2018 Aug 20;14(8):e1007221. doi: 10.1371/journal.ppat.1007221. eCollection 2018 Aug. PLoS Pathog. 2018. PMID: 30125329 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
