Endoplasmic reticulum dysfunction in neurological disease
- PMID: 23237905
- DOI: 10.1016/S1474-4422(12)70238-7
Endoplasmic reticulum dysfunction in neurological disease
Abstract
Endoplasmic reticulum (ER) dysfunction might have an important part to play in a range of neurological disorders, including cerebral ischaemia, sleep apnoea, Alzheimer's disease, multiple sclerosis, amyotrophic lateral sclerosis, the prion diseases, and familial encephalopathy with neuroserpin inclusion bodies. Protein misfolding in the ER initiates the well studied unfolded protein response in energy-starved neurons during stroke, which is relevant to the toxic effects of reperfusion. The toxic peptide amyloid β induces ER stress in Alzheimer's disease, which leads to activation of similar pathways, whereas the accumulation of polymeric neuroserpin in the neuronal ER triggers a poorly understood ER-overload response. In other neurological disorders, such as Parkinson's and Huntington's diseases, ER dysfunction is well recognised but the mechanisms by which it contributes to pathogenesis remain unclear. By targeting components of these signalling responses, amelioration of their toxic effects and so the treatment of a range of neurodegenerative disorders might become possible.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Similar articles
-
Endoplasmic reticulum stress: relevance and therapeutics in central nervous system diseases.Mol Neurobiol. 2015;51(3):1343-52. doi: 10.1007/s12035-014-8813-7. Epub 2014 Jul 22. Mol Neurobiol. 2015. PMID: 25048984 Review.
-
The Common Cellular Events in the Neurodegenerative Diseases and the Associated Role of Endoplasmic Reticulum Stress.Int J Mol Sci. 2022 May 24;23(11):5894. doi: 10.3390/ijms23115894. Int J Mol Sci. 2022. PMID: 35682574 Free PMC article. Review.
-
Mechanisms of disordered neurodegenerative function: concepts and facts about the different roles of the protein kinase RNA-like endoplasmic reticulum kinase (PERK).Rev Neurosci. 2018 Jun 27;29(4):387-415. doi: 10.1515/revneuro-2017-0071. Rev Neurosci. 2018. PMID: 29303785 Review.
-
Endoplasmic Reticulum Stress-Associated Neuronal Death and Innate Immune Response in Neurological Diseases.Front Immunol. 2022 Jan 10;12:794580. doi: 10.3389/fimmu.2021.794580. eCollection 2021. Front Immunol. 2022. PMID: 35082783 Free PMC article. Review.
-
The role of endoplasmic reticulum stress in neurodegenerative disease.Apoptosis. 2017 Jan;22(1):1-26. doi: 10.1007/s10495-016-1296-4. Apoptosis. 2017. PMID: 27815720 Review.
Cited by
-
Mitigating Traumatic Brain Injury: A Narrative Review of Supplementation and Dietary Protocols.Nutrients. 2024 Jul 26;16(15):2430. doi: 10.3390/nu16152430. Nutrients. 2024. PMID: 39125311 Free PMC article. Review.
-
The unfolded protein response: mechanisms and therapy of neurodegeneration.Brain. 2016 Aug;139(Pt 8):2113-21. doi: 10.1093/brain/aww101. Epub 2016 May 11. Brain. 2016. PMID: 27190028 Free PMC article. Review.
-
Proteomic analyses of brain tumor cell lines amidst the unfolded protein response.Oncotarget. 2016 Jul 26;7(30):47831-47847. doi: 10.18632/oncotarget.10032. Oncotarget. 2016. PMID: 27323862 Free PMC article.
-
Inhibition of the ISR abrogates mGluR5-dependent long-term depression and spatial memory deficits in a rat model of Alzheimer's disease.Transl Psychiatry. 2022 Mar 8;12(1):96. doi: 10.1038/s41398-022-01862-9. Transl Psychiatry. 2022. PMID: 35260557 Free PMC article.
-
A trans-acting protein effect causes severe eye malformation in the Mp mouse.PLoS Genet. 2013;9(12):e1003998. doi: 10.1371/journal.pgen.1003998. Epub 2013 Dec 12. PLoS Genet. 2013. PMID: 24348270 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical