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Review
. 2012 Dec 21;6(12):10438-48.
doi: 10.1021/nn3052499. Epub 2012 Dec 7.

Emerging techniques in proteomics for probing nano-bio interactions

Zon W Lai  1 , Yan Yan, Frank Caruso, Edouard C Nice
Affiliations
Review

Emerging techniques in proteomics for probing nano-bio interactions

Zon W Lai et al. ACS Nano. .

Abstract

Nanoengineered particles that can facilitate drug formulation and improve specificity of delivery afford exciting opportunities for improved lesion-specific therapy. Understanding and controlling the nano-bio interactions of these materials is central to future developments in this area. Mass-spectrometry-based proteomics techniques, in conjunction with other emerging technologies, are enabling novel insights into the modulation of particle surfaces by biological fluids (formation of the protein corona) and subsequent particle-induced cellular responses. In this Perspective, we summarize important recent developments using proteomics-based techniques to understand nano-bio interactions and discuss the impact of such knowledge on improving particle design.

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