Intermittent fasting: a "new" historical strategy for controlling seizures?
- PMID: 23206889
- PMCID: PMC3740951
- DOI: 10.1016/j.eplepsyres.2012.10.011
Intermittent fasting: a "new" historical strategy for controlling seizures?
Abstract
In antiquity, fasting was a treatment for epilepsy and a rationale for the ketogenic diet (KD). Preclinical data indicate the KD and intermittent fasting do not share identical anticonvulsant mechanisms. We implemented an intermittent fasting regimen in six children with an incomplete response to a KD. Three patients adhered to the combined intermittent fasting/KD regimen for 2 months and four had transient improvement in seizure control, albeit with some hunger-related adverse reactions.
Copyright © 2012 Elsevier B.V. All rights reserved.
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References
-
- Bailey EE, Pfeifer HH, Thiele EA. The use of diet in the treatment of epilepsy. Epilepsy Behav. 2005;6:4–8. - PubMed
-
- Bergqvist AG, Schall JI, Gallagher PR, Cnaan A, Stallings VA. Fasting versus gradual initiation of the ketogenic diet: a prospective, randomized clinical trial of efficacy. Epilepsia. 2005;46:1810–1819. - PubMed
-
- Bough KJ, Schwartzkroin PA, Rho JM. Calorie restriction and ketogenic diet diminish neuronal excitability in rat dentate gyrus in vivo. Epilepsia. 2003;44:752–760. - PubMed
-
- Bruce-Keller AJ, Umberger G, Mcfall R, Mattson MP. Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults. Ann. Neurol. 1999;45:8–15. - PubMed
-
- Conklin HW. Cause and treatment of epilepsy. J, Am. Osteopath. Assoc. 1922;26:11–14.
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