doi: 10.1038/344410a0.
A sodium-potassium switch in the formation of four-stranded G4-DNA
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- PMID: 2320109
- DOI: 10.1038/344410a0
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A sodium-potassium switch in the formation of four-stranded G4-DNA
Nature.
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Abstract
Single-stranded complex guanine-rich DNA sequences from chromosomal telomeres and elsewhere can associate to form stable parallel four-stranded structures termed G4-DNA by a process that is anomalously dependent on the particular alkali metal cation that is present. The anomaly, which is not found in the formation of G4-DNA by oligonucleotides containing short, single runs of three or more guanines, is caused by potassium cations excessively stabilizing fold-back intermediate structures, or pathway by-products.
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