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Review
. 2013 Feb;191(1):27-34.
doi: 10.1007/s00408-012-9440-6. Epub 2012 Nov 23.

Meta-analysis: the association between HIV infection and extrapulmonary tuberculosis

Cho Naing  1 , Joon Wah Mak, Mala Maung, Shew Fung Wong, Ani Izzuani Binti Mohd Kassim
Affiliations
Review

Meta-analysis: the association between HIV infection and extrapulmonary tuberculosis

Cho Naing et al. Lung. 2013 Feb.

Abstract

Background: Extrapulmonary tuberculosis has been an AIDS-defining condition. Individual studies that highlight the association between HIV and extrapulmonary TB are available. Our objectives were to synthesis evidence on the association between extrapulmonary tuberculosis and HIV and to explore the effective preventive measures of these two diseases.

Methods: This is a meta-analysis of observational studies reporting effect estimates on how HIV is associated with extrapulmonary tuberculosis. We searched for the eligible studies in the electronic databases using search terms related to HIV and extrapulmonary tuberculosis. Where possible, we estimated the summary odds ratios using random effects meta-analysis. We stratified analysis by the type of study design. We assessed heterogeneity of effect estimates within each group of studies was assessed using I (2) test.

Results: Nineteen studies (7 case control studies and 12 cohort studies) were identified for the present study. The pooled analysis shows a significant association between HIV and extrapulmonary tuberculosis (summary odds ratio: 1.3; 95 % confidence interval (CI) 1.05-1.6; I (2): 0 %). In a subgroup analysis with two studies, a significant association was found between CD4+ count less than 100 and the incidence of extrapulmonary tuberculosis (summary OR: 1.31; 95 % CI 1.02-1.68; I (2): 0 %).

Conclusions: Findings show evidence on the association between extrapulmonary tuberculosis and HIV, based on case control studies. Further studies to understand the mechanisms of interaction of the two pathogens are recommended.

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References

    1. Clin Infect Dis. 2012 Jul;55(1):75-81 - PubMed
    1. Indian J Pathol Microbiol. 2010 Apr-Jun;53(2):227-31 - PubMed
    1. J Ayub Med Coll Abbottabad. 2008 Apr-Jun;20(2):43-6 - PubMed
    1. Arch Dis Child. 2000 Oct;83(4):342-6 - PubMed
    1. J Epidemiol Community Health. 2012 Jun;66(6):519-23 - PubMed

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