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. 2012 Sep 1;1(6):986-988.
doi: 10.4161/onci.20213.

Won't you come on in? How to favor lymphocyte infiltration in tumors

Matteo Bellone  1 , Arianna Calcinotto, Angelo Corti
Affiliations

Won't you come on in? How to favor lymphocyte infiltration in tumors

Matteo Bellone et al. Oncoimmunology. .

Abstract

Abnormal tumor vasculature and endothelial cell anergy limit tumor/T-cell interactions. We have found that NGR-TNF, a tumor vasculature-homing derivative of TNF, selectively activates endothelial cells in neoplastic tissues and induces the release of chemokines that favor tumor infiltration by T cells, thereby enhancing the efficacy of active and adoptive immunotherapy.

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Figures

Figure 1.
Figure 1.
Effects of NGR-TNF on tumor microenvironment and T cell infiltration. (A) Increased interstitial pressure, heterogeneous permeability and irregular blood flow, together with reduced expression of adhesion molecules on EC, limit lymphocyte penetration in tumors. (B) NGR-TNF, which selectively binds CD13 expressed in EC of neoangiogenic vessels and favors the interaction of TNF with TNF receptors (TNF-R), alters tumor vessel permeability by loosening VE-cadherin dependent adherence junctions (1), induces upregulation of adhesion molecules in EC (2), and elicits the release of pro-inflammatory cytokines and chemokines (3), thereby favoring the recruitment and extravasation of T lymphocytes.
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