Comment
doi: 10.1126/science.1231310.
Immunology. Cooperative transcription factor complexes in control
Affiliations
- PMID: 23161983
- PMCID: PMC3621126
- DOI: 10.1126/science.1231310
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Comment
Immunology. Cooperative transcription factor complexes in control
Science.
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Erratum in
- Science. 2012 Dec 7;338(6112):1287
Abstract
The cooperative binding of transcription factors regulates the differentiation of T cells as well as the generation and function of B cells and dendritic cells.
Figures
A model of the BATF-Jun-IRF4 complex (1) is shown, based on the known structures of the Jun-ATF2-IRF3B complex in the interferon-β-enhanceosome (14) and the PU.1-IRF4 complex on the IgL λgene enhancer (15). The model was built using AICE motifs from Ctla4 (4 bp spacing) and Bcl11b (0 bp spacing) loci. The sequences of the Ctla4 (left), and Bcl11b (right) AICE elements are shown. The different outcomes of cooperation between IRF4 and BATF-Jun in the immune system are listed.
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