doi: 10.1038/344309a0.
Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice
Affiliations
- PMID: 2314472
- DOI: 10.1038/344309a0
Item in Clipboard
Developmental regulation of human fetal-to-adult globin gene switching in transgenic mice
Nature.
.
Abstract
Transgenic mice containing a human fetal (gamma-) or adult (beta-) globin gene linked to the beta-globin gene locus activation region (LAR) express the gene throughout development. By contrast, transgenic mice containing LAR linked to both a fetal and an adult globin gene display the normal developmental switch from fetal to adult gene expression. This suggests that the human fetal-to-adult globin gene switch is controlled through a mutually exclusive interaction between LAR and either the gamma- or beta-globin gene, resulting in the expression of only one gene at any given moment.
Similar articles
-
The 5'HS4 core element of the human beta-globin locus control region is required for high-level globin gene expression in definitive but not in primitive erythropoiesis.J Mol Biol. 2001 Sep 7;312(1):17-26. doi: 10.1006/jmbi.2001.4939. J Mol Biol. 2001. PMID: 11545582
-
Human gamma-globin genes silenced independently of other genes in the beta-globin locus.Nature. 1991 Mar 21;350(6315):252-4. doi: 10.1038/350252a0. Nature. 1991. PMID: 1706482
-
Role of intergenic human gamma-delta-globin sequences in human hemoglobin switching and reactivation of fetal hemoglobin in adult erythroid cells.Ann N Y Acad Sci. 2005;1054:48-54. doi: 10.1196/annals.1345.057. Ann N Y Acad Sci. 2005. PMID: 16339651 Review.
-
Analysis of the developmental and transcriptional potentiation functions of 5'HS2 of the murine beta-globin locus control region in transgenic mice.Dev Biol. 1994 Oct;165(2):574-84. doi: 10.1006/dbio.1994.1277. Dev Biol. 1994. PMID: 7958423
-
Human globin locus activation region (LAR): role in temporal control.Trends Genet. 1990 Jul;6(7):219-23. doi: 10.1016/0168-9525(90)90182-6. Trends Genet. 1990. PMID: 2202110 Review.
Cited by
-
Reawakening fetal hemoglobin: prospects for new therapies for the β-globin disorders.Blood. 2012 Oct 11;120(15):2945-53. doi: 10.1182/blood-2012-06-292078. Epub 2012 Aug 17. Blood. 2012. PMID: 22904296 Free PMC article. Review.
-
Human beta-globin locus control region: analysis of the 5' DNase I hypersensitive site HS 2 in transgenic mice.Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1626-30. doi: 10.1073/pnas.88.5.1626. Proc Natl Acad Sci U S A. 1991. PMID: 2000371 Free PMC article.
-
Recent Approaches for Manipulating Globin Gene Expression in Treating Hemoglobinopathies.Front Genome Ed. 2021 Aug 2;3:618111. doi: 10.3389/fgeed.2021.618111. eCollection 2021. Front Genome Ed. 2021. PMID: 34713248 Free PMC article. Review.
-
Class switching in B cells lacking 3' immunoglobulin heavy chain enhancers.J Exp Med. 1998 Oct 19;188(8):1421-31. doi: 10.1084/jem.188.8.1421. J Exp Med. 1998. PMID: 9782119 Free PMC article.
-
Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene.Proc Natl Acad Sci U S A. 1993 Apr 15;90(8):3177-81. doi: 10.1073/pnas.90.8.3177. Proc Natl Acad Sci U S A. 1993. PMID: 8475058 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
