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Meta-Analysis
. 2012 Dec;44(12):1341-8.
doi: 10.1038/ng.2467. Epub 2012 Nov 11.

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Lam C Tsoi  1 , Sarah L Spain, Jo Knight, Eva Ellinghaus, Philip E Stuart, Francesca Capon, Jun Ding, Yanming Li, Trilokraj Tejasvi, Johann E Gudjonsson, Hyun M Kang, Michael H Allen, Ross McManus, Giuseppe Novelli, Lena Samuelsson, Joost Schalkwijk, Mona Ståhle, A David Burden, Catherine H Smith, Michael J Cork, Xavier Estivill, Anne M Bowcock, Gerald G Krueger, Wolfgang Weger, Jane Worthington, Rachid Tazi-Ahnini, Frank O Nestle, Adrian Hayday, Per Hoffmann, Juliane Winkelmann, Cisca Wijmenga, Cordelia Langford, Sarah Edkins, Robert Andrews, Hannah Blackburn, Amy Strange, Gavin Band, Richard D Pearson, Damjan Vukcevic, Chris C A Spencer, Panos Deloukas, Ulrich Mrowietz, Stefan Schreiber, Stephan Weidinger, Sulev Koks, Külli Kingo, Tonu Esko, Andres Metspalu, Henry W Lim, John J Voorhees, Michael Weichenthal, H Erich Wichmann, Vinod Chandran, Cheryl F Rosen, Proton Rahman, Dafna D Gladman, Christopher E M Griffiths, Andre Reis, Juha Kere; Collaborative Association Study of Psoriasis (CASP); Genetic Analysis of Psoriasis Consortium; Psoriasis Association Genetics Extension; Wellcome Trust Case Control Consortium 2; Rajan P Nair, Andre Franke, Jonathan N W N Barker, Goncalo R Abecasis, James T Elder, Richard C Trembath
Collaborators, Affiliations
Meta-Analysis

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Lam C Tsoi et al. Nat Genet. 2012 Dec.

Abstract

To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional analyses, five independent signals within previously known loci. The newly identified loci shared with other autoimmune diseases include candidate genes with roles in regulating T-cell function (such as RUNX3, TAGAP and STAT3). Notably, they included candidate genes whose products are involved in innate host defense, including interferon-mediated antiviral responses (DDX58), macrophage activation (ZC3H12C) and nuclear factor (NF)-κB signaling (CARD14 and CARM1). These results portend a better understanding of shared and distinctive genetic determinants of immune-mediated inflammatory disorders and emphasize the importance of the skin in innate and acquired host defense.

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Conflict of interest statement

COMPETING FINANCIAL INTERESTS

The authors declare no competing financial interests.

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References

    1. Nestle FO, Kaplan DH, Barker J. Psoriasis. N Engl J Med. 2009;361:496–509. - PubMed
    1. Elder JT, et al. Molecular dissection of psoriasis: integrating genetics and biology. J Invest Dermatol. 2010;130:1213–26. - PubMed
    1. Ellinghaus E, et al. Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat Genet. 2010;42:991–5. - PMC - PubMed
    1. Nair RP, et al. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet. 2009;41:199–204. - PMC - PubMed
    1. Strange A, et al. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. Nat Genet. 2010;42:985–90. - PMC - PubMed

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