Review
doi: 10.1016/j.semcdb.2012.09.013.
Epub 2012 Oct 8.
Regeneration: the ultimate example of wound healing
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- PMID: 23059793
- DOI: 10.1016/j.semcdb.2012.09.013
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Review
Regeneration: the ultimate example of wound healing
Semin Cell Dev Biol.
2012 Dec.
Abstract
The outcome of wound repair in mammals is often characterized by fibrotic scaring. Vertebrates such as zebrafish, frogs, and salamanders not only heal scarlessly, but also can regenerate lost appendages. Decades of study on the process of animal regeneration has produced key insights into the mechanisms of how complex tissue is restored. By examining our current knowledge of regeneration, we can draw parallels with mammalian wound healing to identify the molecular determinants that produce such differing outcomes.
Copyright © 2012 Elsevier Ltd. All rights reserved.
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