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. 2012 Oct 4;367(14):1355-60.
doi: 10.1056/NEJMsr1203730.

The prevention and treatment of missing data in clinical trials

Roderick J Little  1 , Ralph D'Agostino, Michael L Cohen, Kay Dickersin, Scott S Emerson, John T Farrar, Constantine Frangakis, Joseph W Hogan, Geert Molenberghs, Susan A Murphy, James D Neaton, Andrea Rotnitzky, Daniel Scharfstein, Weichung J Shih, Jay P Siegel, Hal Stern
Affiliations

The prevention and treatment of missing data in clinical trials

Roderick J Little et al. N Engl J Med. .
No abstract available

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Comment in

  • Missing data in clinical trials.
    Lewis HD Jr. Lewis HD Jr. N Engl J Med. 2012 Dec 27;367(26):2557; author reply 2557-8. doi: 10.1056/NEJMc1213388. N Engl J Med. 2012. PMID: 23268683 No abstract available.
  • Missing data in clinical trials.
    Hirman J, Flyer P. Hirman J, et al. N Engl J Med. 2012 Dec 27;367(26):2557; author reply 2557-8. doi: 10.1056/NEJMc1213388. N Engl J Med. 2012. PMID: 23268684 No abstract available.

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References

    1. O’Neill RT, Temple R. The prevention and treatment of missing data in clinical trials: an FDA perspective on the importance of dealing with it. Clin Pharmacol Ther. 2012;91:550–4. - PubMed
    1. Statistical principles for clinical trials; step 5: note for guidance on statistical principles for clinical trials: International Conference on Harmonisation, Topic E9. London: European Medicines Agency; 1998. ( http://www.ich.org/products/guidelines/efficacy/article/efficacy-guideli...)
    1. Committee for Medical Products for Human Use. Guideline on missing data in confirmatory clinical trials. London: European Medicines Evaluation Agency; Apr, 2009. ( http://www.ema.europa.eu/pdfs/human/ewp/177699endraft.pdf)
    1. ICH harmonised tripartite guideline: choice of control group and related issues in clinical trials: International Conference on Harmonisation, Topic E10. London: European Medicines Agency; 2001. ( http://www.ema.europa.eu/pdfs/human/ich/036496en.pdf)
    1. National Research Council. The prevention and treatment of missing data in clinical trials. Washington, DC: National Academies Press; 2010. ( http://www.nap.edu/catalog.php?record_id-12955) - PubMed

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