Ginger extract and zingerone ameliorated trinitrobenzene sulphonic acid-induced colitis in mice via modulation of nuclear factor-κB activity and interleukin-1β signalling pathway
- PMID: 23017409
- DOI: 10.1016/j.foodchem.2012.07.124
Ginger extract and zingerone ameliorated trinitrobenzene sulphonic acid-induced colitis in mice via modulation of nuclear factor-κB activity and interleukin-1β signalling pathway
Abstract
Ginger is a commonly used spice with anti-inflammatory potential. Colitis is the common pathological lesion of inflammatory bowel diseases. In this study, we investigated the therapeutic effects of ginger and its component zingerone in mice with 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis. Ginger and zingerone ameliorated TNBS-induced colonic injury in a dose-dependent manner. Pathway analysis of ginger- and zingerone-regulated gene expression profiles showed that ginger and zingerone significantly regulated cytokine-related pathways. Network analysis showed that nuclear factor-κB (NF-κB) and interleukin-1β (IL-1β) were key molecules involved in the expression of ginger- and zingerone-affected genes. Ex vivo imaging and immunohistochemical staining further verified that ginger and zingerone suppressed TNBS-induced NF-κB activation and IL-1β protein level in the colon. In conclusion, ginger improved TNBS-induced colitis via modulation of NF-κB activity and IL-1β signalling pathway. Moreover, zingerone might be the active component of ginger responsible for the amelioration of colitis induced by TNBS.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Similar articles
-
Ginger and Zingerone Ameliorate Lipopolysaccharide-Induced Acute Systemic Inflammation in Mice, Assessed by Nuclear Factor-κB Bioluminescent Imaging.J Agric Food Chem. 2015 Jul 8;63(26):6051-8. doi: 10.1021/acs.jafc.5b01801. Epub 2015 Jun 24. J Agric Food Chem. 2015. PMID: 26073629
-
Efficacy of thalidomide on trinitrobenzene sulfonate-induced colitis in young rats and its mechanism.Chin Med J (Engl). 2014;127(12):2368-75. Chin Med J (Engl). 2014. PMID: 24931258
-
Inhibition of proprotein convertase subtilisin/kexin type 9 attenuates 2,4,6-trinitrobenzenesulfonic acid-induced colitis via repressing toll-like receptor 4/nuclear factor-kappa B.Kaohsiung J Med Sci. 2020 Sep;36(9):705-711. doi: 10.1002/kjm2.12225. Epub 2020 May 12. Kaohsiung J Med Sci. 2020. PMID: 32396274
-
A Review on Pharmacological Properties of Zingerone (4-(4-Hydroxy-3-methoxyphenyl)-2-butanone).ScientificWorldJournal. 2015;2015:816364. doi: 10.1155/2015/816364. Epub 2015 May 27. ScientificWorldJournal. 2015. PMID: 26106644 Free PMC article. Review.
-
Radioprotective effects of Zingiber officinale Roscoe (ginger): past, present and future.Food Funct. 2012 Jul;3(7):714-23. doi: 10.1039/c2fo10225k. Epub 2012 May 18. Food Funct. 2012. PMID: 22596078 Review.
Cited by
-
Electroacupuncture at Zusanli regulates the pathological phenotype of inflammatory bowel disease by modulating the NLRP3 inflammasome pathway.Immun Inflamm Dis. 2024 Aug;12(8):e1366. doi: 10.1002/iid3.1366. Immun Inflamm Dis. 2024. PMID: 39119947 Free PMC article.
-
Zingerone attenuates intestinal injury and colitis caused by a high-fat diet through Nrf2 signaling regulation.Saudi J Biol Sci. 2023 Oct;30(10):103775. doi: 10.1016/j.sjbs.2023.103775. Epub 2023 Aug 11. Saudi J Biol Sci. 2023. PMID: 37766888 Free PMC article.
-
Antioxidant Activity in Extracts from Zingiberaceae Family: Cardamom, Turmeric, and Ginger.Molecules. 2023 May 11;28(10):4024. doi: 10.3390/molecules28104024. Molecules. 2023. PMID: 37241765 Free PMC article. Review.
-
Leaky Gut and the Ingredients That Help Treat It: A Review.Molecules. 2023 Jan 7;28(2):619. doi: 10.3390/molecules28020619. Molecules. 2023. PMID: 36677677 Free PMC article. Review.
-
Protective Effects of Protopanaxatriol Saponins on Ulcerative Colitis in Mouse Based on UPLC-Q/TOF-MS Serum and Colon Metabolomics.Molecules. 2022 Nov 30;27(23):8346. doi: 10.3390/molecules27238346. Molecules. 2022. PMID: 36500439 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
