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Review
. 2012 Nov;181(5):1504-12.
doi: 10.1016/j.ajpath.2012.07.008. Epub 2012 Sep 4.

Androgen receptor influences on body defense system via modulation of innate and adaptive immune systems: lessons from conditional AR knockout mice

Jiann-Jyh Lai  1 , Kuo-Pao Lai, Weiping Zeng, Kuang-Hsiang Chuang, Saleh Altuwaijri, Chawnshang Chang
Affiliations
Review

Androgen receptor influences on body defense system via modulation of innate and adaptive immune systems: lessons from conditional AR knockout mice

Jiann-Jyh Lai et al. Am J Pathol. 2012 Nov.

Abstract

Upon insult, such as infection or tissue injury, the innate and adaptive immune systems initiate a series of responses to defend the body. Recent studies from immune cell-specific androgen receptor (AR) knockout mice demonstrated that androgen and its receptor (androgen/AR) play significant roles in both immune regulations. In the innate immunity, androgen/AR is required for generation and proper function of neutrophils; androgen/AR also regulates wound healing processes through macrophage recruitment and proinflammatory cytokine production. In adaptive immunity, androgen/AR exerts suppressive effects on development and activation of T and B cells. Removal of such suppression causes thymic enlargement and excessive export of immature B cells. Altogether, androgen/AR plays distinct roles in individual immune cells, and targeting androgen/AR may help in treatment and management of immune-related diseases.

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Figures

Figure 1
Figure 1
Roles of AR in the innate and adaptive immune compartments, including macrophages, neutrophils, thymic epithelial cells, T cells, and B cells. The model incorporates phenotypic observation and associated diseases from conditional ARKO mice with AR deletion in macrophages (cutaneous wound healing, organ failure, and immune suppression), neutrophils (organ failure, immune suppression, and sepsis), thymic epithelial cells (thymic involution and bone marrow transplantation grafting efficacy), T cells (autoimmune diseases), and B cells (autoimmune diseases).
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