Consortium biology in immunology: the perspective from the Immunological Genome Project

doi:10.1038/nri3300

Review

. 2012 Oct;12(10):734-40.

doi: 10.1038/nri3300. Epub 2012 Sep 7.

Consortium biology in immunology: the perspective from the Immunological Genome Project

Christophe Benoist¹, Lewis Lanier, Miriam Merad, Diane Mathis; Immunological Genome Project

Collaborators, Affiliations

Collaborators

Immunological Genome Project:
Jeff Ericson, Michio Painter, Scott Davis, Catherine Laplace, Gordon Hyatt, Henry Paik, Katie Rothamel, Richard Cruse, Graeme Doran, Tracy Heng, Natasha Asinovski, Adriana Ortiz-Lopes, Ayla Ergun, Daniel Gray, Ei Wakamatsu, Jonathan Hill, Michael Mingueneau, Daniela Cipolletta, Hideyuki Yoshida, Christophe Benoist, Diane Mathis, Nadia Cohen, Edy Kim, Patrick Brennan, Lydia Lynch, Michael Brenner, James Costello, Jim J Collins, David Blair, Michael Dustin, Jamie Knell, Edward Yang, Adam Best, Laura Shaw, Andrew Doedens, Ananda Goldrath, Susan Shinton, Yan Zhou, Randy Hardy, Vladimir Jojic, Sara Mostafavi, Daphne Koller, Radu Jianu, David Laidlaw, Natalie Bezman, Joseph Sun, Yanan Zhu, Deborah Hendricks, Yosuke Kamimura, Gundula Min-Oo, Deborah Hendricks, Maelig Morvan, Yosuke Kamimura, Tsukasa Nabekura, Viola Lam, Charles Kim, Lewis Lanier, Melanie Greter, Julie Helft, Andrew Chow, Milena Bogunovic, Arthur Mortha, Jeremy Price, Daigo Hashimoto, Jennifer Miller, Priyanka Sathe, Aleksey Chudnovskiy, Yonit Lavin, Juliana Idoyaga, Miriam Merad, Emmanuel Gautier, Claudia Jakubzick, June D'Angelo, Gwendolyn Randolph, Tal Shay, Aviv Regev, Roi Gazit, Derrick Rossi, Taras Kreslawsky, Harald von Bohmer, Angelique Bellemare-Pelletier, Kutlu Elpek, Lotte Spelv, Anne Fletcher, Deepali Malhotra, Viviana Cremasco, Shannon Turley, Francis Kim, Tata Nageswara Rao, Amy Wagers

Affiliation

¹ Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA. cbdm@hms.harvard.edu

PMID: 22955842
DOI: 10.1038/nri3300

Free article

Review

Consortium biology in immunology: the perspective from the Immunological Genome Project

Christophe Benoist et al. Nat Rev Immunol. 2012 Oct.

Free article

. 2012 Oct;12(10):734-40.

doi: 10.1038/nri3300. Epub 2012 Sep 7.

Authors

Christophe Benoist¹, Lewis Lanier, Miriam Merad, Diane Mathis; Immunological Genome Project

Collaborators

Immunological Genome Project:
Jeff Ericson, Michio Painter, Scott Davis, Catherine Laplace, Gordon Hyatt, Henry Paik, Katie Rothamel, Richard Cruse, Graeme Doran, Tracy Heng, Natasha Asinovski, Adriana Ortiz-Lopes, Ayla Ergun, Daniel Gray, Ei Wakamatsu, Jonathan Hill, Michael Mingueneau, Daniela Cipolletta, Hideyuki Yoshida, Christophe Benoist, Diane Mathis, Nadia Cohen, Edy Kim, Patrick Brennan, Lydia Lynch, Michael Brenner, James Costello, Jim J Collins, David Blair, Michael Dustin, Jamie Knell, Edward Yang, Adam Best, Laura Shaw, Andrew Doedens, Ananda Goldrath, Susan Shinton, Yan Zhou, Randy Hardy, Vladimir Jojic, Sara Mostafavi, Daphne Koller, Radu Jianu, David Laidlaw, Natalie Bezman, Joseph Sun, Yanan Zhu, Deborah Hendricks, Yosuke Kamimura, Gundula Min-Oo, Deborah Hendricks, Maelig Morvan, Yosuke Kamimura, Tsukasa Nabekura, Viola Lam, Charles Kim, Lewis Lanier, Melanie Greter, Julie Helft, Andrew Chow, Milena Bogunovic, Arthur Mortha, Jeremy Price, Daigo Hashimoto, Jennifer Miller, Priyanka Sathe, Aleksey Chudnovskiy, Yonit Lavin, Juliana Idoyaga, Miriam Merad, Emmanuel Gautier, Claudia Jakubzick, June D'Angelo, Gwendolyn Randolph, Tal Shay, Aviv Regev, Roi Gazit, Derrick Rossi, Taras Kreslawsky, Harald von Bohmer, Angelique Bellemare-Pelletier, Kutlu Elpek, Lotte Spelv, Anne Fletcher, Deepali Malhotra, Viviana Cremasco, Shannon Turley, Francis Kim, Tata Nageswara Rao, Amy Wagers

Affiliation

¹ Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA. cbdm@hms.harvard.edu

PMID: 22955842
DOI: 10.1038/nri3300

Erratum in

Nat Rev Immunol. 2014 Aug;14(8):578. Cipoletta, Daniela [corrected to Cipolletta, Daniela]

Abstract

Although the field has a long collaborative tradition, immunology has made less use than genetics of 'consortium biology', wherein groups of investigators together tackle large integrated questions or problems. However, immunology is naturally suited to large-scale integrative and systems-level approaches, owing to the multicellular and adaptive nature of the cells it encompasses. Here, we discuss the value and drawbacks of this organization of research, in the context of the long-running 'big science' debate, and consider the opportunities that may exist for the immunology community. We position this analysis in light of our own experience, both positive and negative, as participants of the Immunological Genome Project.

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References

1. Immunology. 2008 Dec;125(4):441-9 - PubMed
1. Science. 1961 Jul 21;134(3473):161-4 - PubMed
1. Immunol Rev. 2006 Apr;210:27-39 - PubMed
1. Nucleic Acids Res. 2010 Jan;38(Database issue):D854-62 - PubMed
1. PLoS One. 2012;7(6):e39315 - PubMed

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[1] Immunology. 2008 Dec;125(4):441-9 - PubMed

[2] Immunology. 2008 Dec;125(4):441-9 - PubMed

[3] Science. 1961 Jul 21;134(3473):161-4 - PubMed

[4] Science. 1961 Jul 21;134(3473):161-4 - PubMed

[5] Immunol Rev. 2006 Apr;210:27-39 - PubMed

[6] Immunol Rev. 2006 Apr;210:27-39 - PubMed

[7] Nucleic Acids Res. 2010 Jan;38(Database issue):D854-62 - PubMed

[8] Nucleic Acids Res. 2010 Jan;38(Database issue):D854-62 - PubMed

[9] PLoS One. 2012;7(6):e39315 - PubMed

[10] PLoS One. 2012;7(6):e39315 - PubMed

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Consortium biology in immunology: the perspective from the Immunological Genome Project

Collaborators

Affiliation

Consortium biology in immunology: the perspective from the Immunological Genome Project

Authors

Collaborators

Affiliation

Erratum in

Abstract

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Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources