PI3K-PKB/Akt pathway

doi:10.1101/cshperspect.a011189

Review

. 2012 Sep 1;4(9):a011189.

doi: 10.1101/cshperspect.a011189.

PI3K-PKB/Akt pathway

Brian A Hemmings¹, David F Restuccia

Affiliations

PMID: 22952397
PMCID: PMC3428770
DOI: 10.1101/cshperspect.a011189

Review

PI3K-PKB/Akt pathway

Brian A Hemmings et al. Cold Spring Harb Perspect Biol. 2012.

. 2012 Sep 1;4(9):a011189.

doi: 10.1101/cshperspect.a011189.

Authors

Brian A Hemmings¹, David F Restuccia

Affiliation

¹ Friedrich Miescher Institute for Biomedical Research, Basel 4058, Switzerland.

PMID: 22952397
PMCID: PMC3428770
DOI: 10.1101/cshperspect.a011189

Erratum in

The PI3K-PKB/Akt pathway.
Hemmings BA, Restuccia DF. Hemmings BA, et al. Cold Spring Harb Perspect Biol. 2015 Apr 1;7(4):a026609. doi: 10.1101/cshperspect.a026609. Cold Spring Harb Perspect Biol. 2015. PMID: 25833846 Free PMC article. No abstract available.

Abstract

Protein kinase B (PKB, or Akt) plays a role in cell metabolism, growth, proliferation, and survival. Its activation is controlled by a multi-step process that involves phosphoinositide-3-kinase (PI3K).

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Figures

**Figure 1.**
PKB/Akt activation downstream of RTKs via the P13K pathway.

**Figure 2.**
Signalling events activating PKB/Akt and cellular functions regulated by PKB/Akt.

See this image and copyright information in PMC

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References

1. Alessi DR 2001. Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture. Biochem Soc Trans 29: 1–14 - PubMed
1. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P 1997. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 7: 261–269 - PubMed
1. Altomare DA, Testa JR 2005. Perturbations of the AKT signaling pathway in human cancer. Oncogene 24: 7455–7464 - PubMed
1. Andjelković M, Jakubowicz T, Cron P, Ming XF, Han JW, Hemmings BA 1996. Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci 93: 5699–5704 - PMC - PubMed
1. Bozulic L, Hemmings BA 2009. PIKKing on PKB: Regulation of PKB activity by phosphorylation. Curr Opin Cell Biol 21: 256–261 - PubMed

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[1] Alessi DR 2001. Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture. Biochem Soc Trans 29: 1–14 - PubMed

[2] Alessi DR 2001. Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture. Biochem Soc Trans 29: 1–14 - PubMed

[3] Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P 1997. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 7: 261–269 - PubMed

[4] Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P 1997. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 7: 261–269 - PubMed

[5] Altomare DA, Testa JR 2005. Perturbations of the AKT signaling pathway in human cancer. Oncogene 24: 7455–7464 - PubMed

[6] Altomare DA, Testa JR 2005. Perturbations of the AKT signaling pathway in human cancer. Oncogene 24: 7455–7464 - PubMed

[7] Andjelković M, Jakubowicz T, Cron P, Ming XF, Han JW, Hemmings BA 1996. Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci 93: 5699–5704 - PMC - PubMed

[8] Andjelković M, Jakubowicz T, Cron P, Ming XF, Han JW, Hemmings BA 1996. Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci 93: 5699–5704 - PMC - PubMed

[9] Bozulic L, Hemmings BA 2009. PIKKing on PKB: Regulation of PKB activity by phosphorylation. Curr Opin Cell Biol 21: 256–261 - PubMed

[10] Bozulic L, Hemmings BA 2009. PIKKing on PKB: Regulation of PKB activity by phosphorylation. Curr Opin Cell Biol 21: 256–261 - PubMed

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PI3K-PKB/Akt pathway

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