Distinct contribution of stem and progenitor cells to epidermal maintenance
- PMID: 22940863
- DOI: 10.1038/nature11393
Distinct contribution of stem and progenitor cells to epidermal maintenance
Abstract
The skin interfollicular epidermis (IFE) is the first barrier against the external environment and its maintenance is critical for survival. Two seemingly opposite theories have been proposed to explain IFE homeostasis. One posits that IFE is maintained by long-lived slow-cycling stem cells that give rise to transit-amplifying cell progeny, whereas the other suggests that homeostasis is achieved by a single committed progenitor population that balances stochastic fate. Here we probe the cellular heterogeneity within the IFE using two different inducible Cre recombinase–oestrogen receptor constructs targeting IFE progenitors in mice. Quantitative analysis of clonal fate data and proliferation dynamics demonstrate the existence of two distinct proliferative cell compartments arranged in a hierarchy involving slow-cycling stem cells and committed progenitor cells. After wounding, only stem cells contribute substantially to the repair and long-term regeneration of the tissue, whereas committed progenitor cells make a limited contribution.
Comment in
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Stem cells: hierarchy in the population.Nat Rev Mol Cell Biol. 2012 Oct;13(10):605. doi: 10.1038/nrm3435. Epub 2012 Sep 5. Nat Rev Mol Cell Biol. 2012. PMID: 22948018 No abstract available.
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Cell biology: Dormant and restless skin stem cells.Nature. 2012 Sep 13;489(7415):215-7. doi: 10.1038/489215a. Nature. 2012. PMID: 22972293 No abstract available.
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