Fusion and fission: interlinked processes critical for mitochondrial health
- PMID: 22934639
- DOI: 10.1146/annurev-genet-110410-132529
Fusion and fission: interlinked processes critical for mitochondrial health
Abstract
Mitochondria are dynamic organelles that continually undergo fusion and fission. These opposing processes work in concert to maintain the shape, size, and number of mitochondria and their physiological function. Some of the major molecules mediating mitochondrial fusion and fission in mammals have been discovered, but the underlying molecular mechanisms are only partially unraveled. In particular, the cast of characters involved in mitochondrial fission needs to be clarified. By enabling content mixing between mitochondria, fusion and fission serve to maintain a homogeneous and healthy mitochondrial population. Mitochondrial dynamics has been linked to multiple mitochondrial functions, including mitochondrial DNA stability, respiratory capacity, apoptosis, response to cellular stress, and mitophagy. Because of these important functions, mitochondrial fusion and fission are essential in mammals, and even mild defects in mitochondrial dynamics are associated with disease. A better understanding of these processes likely will ultimately lead to improvements in human health.
Similar articles
-
[Advances in mitochondrial fusion-fission and Ca2+ signaling in mammals].Sheng Li Ke Xue Jin Zhan. 2010 Jun;41(3):171-6. Sheng Li Ke Xue Jin Zhan. 2010. PMID: 21416975 Review. Chinese.
-
Dysregulation of mitochondrial fusion and fission: an emerging concept in neurodegeneration.Acta Neuropathol. 2006 Feb;111(2):93-100. doi: 10.1007/s00401-005-0002-3. Epub 2006 Feb 9. Acta Neuropathol. 2006. PMID: 16468021 Review.
-
Less than perfect divorces: dysregulated mitochondrial fission and neurodegeneration.Acta Neuropathol. 2012 Feb;123(2):189-203. doi: 10.1007/s00401-011-0930-z. Epub 2011 Dec 17. Acta Neuropathol. 2012. PMID: 22179580 Review.
-
Mitochondrial dynamics in the regulation of neuronal cell death.Apoptosis. 2007 May;12(5):979-92. doi: 10.1007/s10495-007-0745-5. Apoptosis. 2007. PMID: 17453163 Review.
-
[Role of transmembrane GTPases in mitochondrial morphology and activity].Postepy Biochem. 2007;53(1):53-9. Postepy Biochem. 2007. PMID: 17718388 Review. Polish.
Cited by
-
The circadian coordination of cell biology.J Cell Biol. 2016 Oct 10;215(1):15-25. doi: 10.1083/jcb.201603076. J Cell Biol. 2016. PMID: 27738003 Free PMC article. Review.
-
Dynamin-related Protein 1 Inhibition Mitigates Bisphenol A-mediated Alterations in Mitochondrial Dynamics and Neural Stem Cell Proliferation and Differentiation.J Biol Chem. 2016 Jul 29;291(31):15923-39. doi: 10.1074/jbc.M115.709493. Epub 2016 Jun 1. J Biol Chem. 2016. PMID: 27252377 Free PMC article.
-
CaMKIV regulates mitochondrial dynamics during sepsis.Cell Calcium. 2020 Dec;92:102286. doi: 10.1016/j.ceca.2020.102286. Epub 2020 Sep 5. Cell Calcium. 2020. PMID: 32932146 Free PMC article.
-
Cardiolipin's propensity for phase transition and its reorganization by dynamin-related protein 1 form a basis for mitochondrial membrane fission.Mol Biol Cell. 2015 Sep 1;26(17):3104-16. doi: 10.1091/mbc.E15-06-0330. Epub 2015 Jul 8. Mol Biol Cell. 2015. PMID: 26157169 Free PMC article.
-
Altered Endoplasmic Reticulum Integrity and Organelle Interactions in Living Cells Expressing INF2 Variants.Int J Mol Sci. 2024 Sep 10;25(18):9783. doi: 10.3390/ijms25189783. Int J Mol Sci. 2024. PMID: 39337270 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
