Review
New approaches to chromatin function
Affiliations
- PMID: 2279025
Item in Clipboard
Review
New approaches to chromatin function
New Biol.
1990 Mar.
Abstract
Our current knowledge of chromatin structure raises the major issue of the accessibility of DNA to the proteins involved in macromolecular processes such as replication, recombination, and transcription. Recent genetic and biochemical analyses have both proven that chromatin structure plays a role in specifically repressing the initiation of transcription of several genes and suggested how this repression might be overcome in vivo. Such progress in understanding how genes are transcribed in a chromatin environment provides us with important insights into the means by which specific protein-DNA interactions occur within the nucleus.
Similar articles
-
In vivo cross-linking and immunoprecipitation for studying dynamic Protein:DNA associations in a chromatin environment.Methods. 1999 Nov;19(3):425-33. doi: 10.1006/meth.1999.0879. Methods. 1999. PMID: 10579938 Review.
-
Remodeling chromatin structures for transcription: what happens to the histones?Bioessays. 1996 Nov;18(11):875-84. doi: 10.1002/bies.950181106. Bioessays. 1996. PMID: 8939065 Review.
-
Experimental analysis of chromatin function in transcription control.Crit Rev Eukaryot Gene Expr. 1994;4(4):403-41. Crit Rev Eukaryot Gene Expr. 1994. PMID: 7734837 Review.
-
Retinoid receptors in health and disease: co-regulators and the chromatin connection.Semin Cell Dev Biol. 1999 Apr;10(2):215-25. doi: 10.1006/scdb.1999.0303. Semin Cell Dev Biol. 1999. PMID: 10441075 Review.
-
Measurement of protein-DNA interactions in vivo by chromatin immunoprecipitation.Methods Mol Biol. 2004;284:129-46. doi: 10.1385/1-59259-816-1:129. Methods Mol Biol. 2004. PMID: 15173613
Cited by
-
Cisplatin inhibits chromatin remodeling, transcription factor binding, and transcription from the mouse mammary tumor virus promoter in vivo.Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2076-80. doi: 10.1073/pnas.92.6.2076. Proc Natl Acad Sci U S A. 1995. PMID: 7892227 Free PMC article.
-
Biochemical and functional characterization of histone H1-like proteins in procyclic Trypanosoma brucei brucei.Parasitol Res. 1993;79(8):649-59. doi: 10.1007/BF00932507. Parasitol Res. 1993. PMID: 8295902
-
Aphidicolin-resistant polyomavirus and subgenomic cellular DNA synthesis occur early in the differentiation of cultured myoblasts to myotubes.J Virol. 1993 Jul;67(7):4169-81. doi: 10.1128/JVI.67.7.4169-4181.1993. J Virol. 1993. PMID: 8389922 Free PMC article.
-
Binding of TFIID to the CYC1 TATA boxes in yeast occurs independently of upstream activating sequences.Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11909-13. doi: 10.1073/pnas.91.25.11909. Proc Natl Acad Sci U S A. 1994. PMID: 7991556 Free PMC article.
-
Analysis of CpG methylation and genomic footprinting at the tyrosine aminotransferase gene: DNA methylation alone is not sufficient to prevent protein binding in vivo.EMBO J. 1991 Sep;10(9):2559-67. doi: 10.1002/j.1460-2075.1991.tb07796.x. EMBO J. 1991. PMID: 1714382 Free PMC article.