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. 2012 Jun 29:3:234.
doi: 10.3389/fmicb.2012.00234. eCollection 2012.

Association of MHC-I genotypes with disease progression in HIV/SIV infections

Takushi Nomura  1 , Tetsuro Matano
Affiliations

Association of MHC-I genotypes with disease progression in HIV/SIV infections

Takushi Nomura et al. Front Microbiol. .

Abstract

Virus-specific cytotoxic T lymphocytes (CTLs) are major effectors in acquired immune responses against viral infection. Virus-specific CTLs recognize specific viral peptides presented by major histocompatibility complex class-I (MHC-I) on the surface of virus-infected target cells via their T cell receptor (TCR) and eliminate target cells by both direct and indirect mechanisms. In human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections, host immune responses fail to contain the virus and allow persistent viral replication, leading to AIDS progression. CTL responses exert strong suppressive pressure on HIV/SIV replication and cumulative studies have indicated association of HLA/MHC-I genotypes with rapid or slow AIDS progression.

Keywords: CTL; HIV; HLA; MHC-I; MHC-I haplotype; Mamu; SIV.

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Figures

FIGURE 1
FIGURE 1
Comparison of genome structures of MHC-I sub-regions in humans and rhesus macaques. Humans have a single polymorphic HLA-A, HLA-B, and HLA-C locus per chromosome, while rhesus macaques have variable numbers of Mamu-A and Mamu-B loci per chromosome.
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