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. 2012 Aug;134(3):1291-5.
doi: 10.1007/s10549-012-2144-z. Epub 2012 Jul 3.

Association of sleep duration and breast cancer OncotypeDX recurrence score

Cheryl L Thompson  1 , Li Li
Affiliations

Association of sleep duration and breast cancer OncotypeDX recurrence score

Cheryl L Thompson et al. Breast Cancer Res Treat. 2012 Aug.

Abstract

Shorter duration of sleep has been associated with risk of a number of medical conditions, including breast cancer. However, no prior study has investigated the relationship of average sleep duration before diagnosis and cancer aggressiveness. OncotypeDX is a widely utilized test to guide treatment in early stage hormone receptor positive breast cancer by predicting likelihood of recurrence. We reviewed medical records from ER+ early stage breast cancer patients participating in a case-control study for availability of OncotypeDX scores. All patients in the parent study were recruited at diagnosis and asked about average sleep duration in the 2 years before diagnosis. We analyzed data from 101 breast cancer patients with available OncotypeDX recurrence scores to test the hypothesis that shorter sleep is associated with greater likelihood of recurrence. We found that OncotypeDX recurrence scores were strongly correlated with average hours of sleep per night before breast cancer diagnosis, with fewer hours of sleep associated with a higher (worse) recurrence score (R = -0.30, p = 0.0031). This correlation was limited to post-menopausal breast cancer patients only (R = -0.41, p = 0.0011, for postmenopausal patients; R = -0.05, p = 0.80 for pre-menopausal patients). This association remains statistically significant after adjustment for age, physical activity, smoking status, and body mass index in the entire study sample (p = 0.0058) as well as in postmenopausal patients (p = 0.0021). This is the first study to suggest that women who routinely sleep fewer hours may develop more aggressive breast cancers compared with women who sleep longer hours.

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Conflict of interest statement

Conflict of Interest: The authors have no conflicts of interest relevant to the presented research.

Figures

Figure 1
Figure 1
Distribution of OncotypeDX and Average Hours of Sleep
Figure 2
Figure 2. Average Oncotype Score by Hours of Sleep
Mean (with standard error bars) OncotypeDX recurrence score by average reported sleep duration. The first figure shows the entire sample, the second provides average scores for pre-menopausal breast cancer patients only and the third post-menopausal. Reported p for trend values are from logistic regression accounting for age, smoking status, body mass index and physical activity.
Figure 2
Figure 2. Average Oncotype Score by Hours of Sleep
Mean (with standard error bars) OncotypeDX recurrence score by average reported sleep duration. The first figure shows the entire sample, the second provides average scores for pre-menopausal breast cancer patients only and the third post-menopausal. Reported p for trend values are from logistic regression accounting for age, smoking status, body mass index and physical activity.
See this image and copyright information in PMC

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