Pharmacokinetics of the etonogestrel contraceptive implant in obese women
- PMID: 22717269
- DOI: 10.1016/j.ajog.2012.05.002
Pharmacokinetics of the etonogestrel contraceptive implant in obese women
Abstract
Objective: We sought to examine the pharmacokinetics and acceptability of the etonogestrel contraceptive implant in obese women.
Study design: We developed and validated a plasma etonogestrel concentration assay and enrolled 13 obese (body mass index ≥30) women and 4 normal-weight (body mass index <25) women, who ensured comparability with historical controls. Etonogestrel concentrations were measured at 50-hour intervals through 300 hours postinsertion, then at 3 and 6 months to establish a pharmacokinetic curve.
Results: All obese participants were African American, while all normal-weight participants were white. Across time, the plasma etonogestrel concentrations in obese women were lower than published values for normal-weight women and 31-63% lower than in the normal-weight study cohort, although these differences were not statistically significant. The implant device was found highly acceptable among obese women.
Conclusion: Obese women have lower plasma etonogestrel concentration than normal-weight women in the first 6 months after implant insertion. These findings should not be interpreted as decreased contraceptive effectiveness without additional considerations.
Copyright © 2012 Mosby, Inc. All rights reserved.
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