Extragastrointestinal manifestations of Helicobacter pylori infection: facts or myth? A critical review
- PMID: 22713083
- DOI: 10.1111/j.1751-2980.2012.00599.x
Extragastrointestinal manifestations of Helicobacter pylori infection: facts or myth? A critical review
Abstract
Helicobacter pylori (H. pylori) infection is reported to be associated with many extragastrointestinal manifestations, such as hematological diseases [idiopathic thrombocytopenic purpura (ITP) and unexplained iron deficiency anemia (IDA)], cardiovascular diseases (ischemic heart diseases), neurological disorders (stroke, Parkinson's disease, Alzheimer's disease), obesity and skin disorders. Among these, the best evidence so far is in ITP and unexplained IDA, with high-quality studies showing the improvement of IDA and ITP after H. pylori eradication. The evidence of its association with coronary artery disease is weak and many of the results may be erroneous. The role of H. pylori infection in affecting serum leptin and ghrelin levels has attracted a lot of attention recently and available data to date have been conflicting. There have also been many uncontrolled, small sample studies suggesting an association between H. pylori infection and neurological disorders or chronic urticaria. However, more studies are required to clarify such proposed causal links.
© 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd.
Similar articles
-
Extragastric manifestations of Helicobacter pylori infection.Minerva Med. 2006 Feb;97(1):39-45. Minerva Med. 2006. PMID: 16565697 Review.
-
[The role of Helicobacter pylori infection in hematological diseases - a review].Gan To Kagaku Ryoho. 2011 Mar;38(3):358-61. Gan To Kagaku Ryoho. 2011. PMID: 21403437 Review. Japanese.
-
Iron deficiency anemia successfully treated by Helicobacter pylori eradication in a patient with idiopathic thrombocytopenic purpura.Rinsho Ketsueki. 2009 Nov;50(11):1655-7. Rinsho Ketsueki. 2009. PMID: 20009444
-
The role of Helicobacter pylori infection in hematological disorders.Eur J Intern Med. 2013 Dec;24(8):685-90. doi: 10.1016/j.ejim.2013.02.011. Epub 2013 Mar 21. Eur J Intern Med. 2013. PMID: 23523153 Review.
-
Extragastric manifestations of Helicobacter pylori infection--other Helicobacter species.Helicobacter. 2006 Oct;11 Suppl 1:46-51. doi: 10.1111/j.1478-405X.2006.00430.x. Helicobacter. 2006. PMID: 16925612
Cited by
-
H. pylori infection and extra-gastroduodenal diseases.J Biomed Sci. 2018 Aug 29;25(1):65. doi: 10.1186/s12929-018-0469-6. J Biomed Sci. 2018. PMID: 30157866 Free PMC article. Review.
-
Helicobacter pylori-associated immune thrombocytopenia: clinical features and pathogenic mechanisms.World J Gastroenterol. 2014 Jan 21;20(3):714-23. doi: 10.3748/wjg.v20.i3.714. World J Gastroenterol. 2014. PMID: 24574745 Free PMC article. Review.
-
Risk of Ischemic Stroke in Relation to Helicobacter pylori Infection and Eradication Status: A Large-Scale Prospective Observational Cohort Study.Gut Liver. 2024 Jul 15;18(4):642-653. doi: 10.5009/gnl230458. Epub 2024 May 7. Gut Liver. 2024. PMID: 38712396 Free PMC article.
-
Helicobacter pylori infection and micronutrient deficiency in pregnant women: a systematic review and meta-analysis.BMJ Open Gastroenterol. 2020 Oct;7(1):e000490. doi: 10.1136/bmjgast-2020-000490. BMJ Open Gastroenterol. 2020. PMID: 33093020 Free PMC article.
-
Helicobacter pylori infection in Mongolian gerbils does not initiate hematological diseases.World J Gastroenterol. 2014 Sep 14;20(34):12308-12. doi: 10.3748/wjg.v20.i34.12308. World J Gastroenterol. 2014. PMID: 25232266 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical