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. 1990 Dec 11;18(23):6857-62.
doi: 10.1093/nar/18.23.6857.

COUP-TF gene: a structure unique for the steroid/thyroid receptor superfamily

H H Ritchie  1 , L H Wang, S Tsai, B W O'Malley, M J Tsai
Affiliations
Free PMC article

COUP-TF gene: a structure unique for the steroid/thyroid receptor superfamily

H H Ritchie et al. Nucleic Acids Res. .
Free PMC article

Abstract

Two different genomic genes for the COUP-transcription factor, COUP-TF I and COUP-TF II, have been isolated from a human cosmid genomic library using a [32P]-labeled cDNA probe. Data obtained from Southern blot analysis of these cosmid clones indicated that two closely related genes exist in the human genome and have a similar genomic organization. The genes are similar in the hormone and DNA binding domains but diverge from one another in the N-terminal region. Using DNA sequencing and polymerase chain reaction (PCR) techniques we have determined that the structure of COUP-TF I consists only of three exons and two introns. Surprisingly, both zinc fingers (i.e., F1 and F2) are located in the first exon. Therefore, COUP-TF I is unique among the members of the steroid/thyroid hormone receptor superfamily which have been described to date.

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