Acidic preconditioning protects against ischemia-induced brain injury
- PMID: 22583767
- DOI: 10.1016/j.neulet.2012.05.015
Acidic preconditioning protects against ischemia-induced brain injury
Abstract
Ischemic preconditioning protects against cerebral ischemia. Recent investigations indicated that acidic preconditioning (APC) protects against ischemia-induced cardiomyocytes injury. However, it is not clear whether APC can protect against cerebral ischemia. To address this issue, C57BL/6 mice were exposed 3 times at 10-min intervals to a normoxic atmosphere containing 20% CO(2) for 5 min before being further subjected to bilateral common carotid artery occlusion. APC reversed the ischemia-induced brain injury as revealed by improved performance in passive avoidance experiments and decreased neuron loss in the hippocampal CA1 region. Consistently, both APC-treated brain slices and primary cultured neurons were more resistant to oxygen-glucose-deprivation (OGD)-induced injury, in a pH- and time-dependent manner, as revealed by reversed cell/tissue viability. In addition, the APC treatment prevented OGD-induced mitochondrial transmembrane potential loss and apoptosis, which was inhibited by the mitochondrial permeability transport pore opener atractyloside. Taken together, these findings indicated that APC protects against ischemia-induced neuronal injury. The beneficial effects may be attributed, at least in part, to decreased mitochondria-dependent neuronal apoptosis.
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Comment in
-
Preconditioning with hypercapnic acidosis: hope for the ischemic brain.Neurosci Lett. 2012 Aug 8;523(1):1-2. doi: 10.1016/j.neulet.2012.06.005. Epub 2012 Jun 19. Neurosci Lett. 2012. PMID: 22743297
Similar articles
-
Preconditioning with hypercapnic acidosis: hope for the ischemic brain.Neurosci Lett. 2012 Aug 8;523(1):1-2. doi: 10.1016/j.neulet.2012.06.005. Epub 2012 Jun 19. Neurosci Lett. 2012. PMID: 22743297
-
Sevoflurane preconditioning improves mitochondrial function and long-term neurologic sequelae after transient cerebral ischemia: role of mitochondrial permeability transition.Crit Care Med. 2012 Sep;40(9):2685-93. doi: 10.1097/CCM.0b013e318258fb90. Crit Care Med. 2012. PMID: 22732280
-
Hyperbaric oxygen preconditioning protects cortical neurons against oxygen-glucose deprivation injury: role of peroxisome proliferator-activated receptor-gamma.Brain Res. 2012 May 3;1452:140-50. doi: 10.1016/j.brainres.2012.02.063. Epub 2012 Mar 6. Brain Res. 2012. PMID: 22444276
-
A double-edged sword with therapeutic potential: an updated role of autophagy in ischemic cerebral injury.CNS Neurosci Ther. 2012 Nov;18(11):879-86. doi: 10.1111/cns.12005. Epub 2012 Sep 24. CNS Neurosci Ther. 2012. PMID: 22998350 Free PMC article. Review.
-
The therapeutic window in ischemic brain injury.Curr Opin Neurol. 1995 Feb;8(1):3-5. doi: 10.1097/00019052-199502000-00002. Curr Opin Neurol. 1995. PMID: 7749513 Review. No abstract available.
Cited by
-
Ac-YVAD-cmk ameliorated sevoflurane-induced cognitive dysfunction and revised mitophagy impairment.PLoS One. 2023 Jan 25;18(1):e0280914. doi: 10.1371/journal.pone.0280914. eCollection 2023. PLoS One. 2023. PMID: 36696410 Free PMC article.
-
PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window.Autophagy. 2017 Mar 4;13(3):473-485. doi: 10.1080/15548627.2016.1274596. Epub 2017 Jan 19. Autophagy. 2017. PMID: 28103118 Free PMC article.
-
Mitochondria-Related Ferroptosis Drives Cognitive Deficits in Neonatal Mice Following Sevoflurane Administration.Front Med (Lausanne). 2022 Jul 22;9:887062. doi: 10.3389/fmed.2022.887062. eCollection 2022. Front Med (Lausanne). 2022. PMID: 35935755 Free PMC article.
-
Inhibition of G protein-coupled receptor 81 (GPR81) protects against ischemic brain injury.CNS Neurosci Ther. 2015 Mar;21(3):271-9. doi: 10.1111/cns.12362. Epub 2014 Dec 11. CNS Neurosci Ther. 2015. PMID: 25495836 Free PMC article.
-
Neuroprotective Role of Acidosis in Ischemia: Review of the Preclinical Evidence.Mol Neurobiol. 2021 Dec;58(12):6684-6696. doi: 10.1007/s12035-021-02578-5. Epub 2021 Oct 4. Mol Neurobiol. 2021. PMID: 34606050 Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous