Review
doi: 10.1016/j.febslet.2012.02.001.
Epub 2012 Feb 11.
Phosphatases in SMAD regulation
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- PMID: 22576046
- DOI: 10.1016/j.febslet.2012.02.001
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Review
Phosphatases in SMAD regulation
FEBS Lett.
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Free article
Abstract
SMAD transcription factors are key mediators of the transforming growth factor-beta (TGFß) family of cytokines. Reversible phosphorylation of SMAD proteins plays a key role in regulating their function. Several phosphatases have been proposed to act on SMAD proteins to influence TGFß/BMP signalling. Here we provide an overview of the SMAD regulation by different protein phosphatases and review the evidence supporting each phosphatase as a candidate SMAD-phosphatase.
Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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