Topical lavender oil for the treatment of recurrent aphthous ulceration
- PMID: 22558691
Topical lavender oil for the treatment of recurrent aphthous ulceration
Abstract
Purpose: To determine the laboratory and clinical efficacy of lavender oil in the treatment of recurrent aphthous ulceration (RAU).
Methods: This was a randomized double-blind, placebo-controlled study performed firstly to treat the induced ulcers by different methods in experimental animals (rabbits) treated with lavender oil or placebo. Clinical and histological healing was established by measuring the area of the ulcer and inflammation levels in each test group. Secondly, safety/toxicity; the median lethal dose (LD50) was studied in albino mice, and dermal irritation test was performed by primary irritation to the skin and measured by a patch-test technique on the intact skin of the albino rabbit. Thirdly, antibacterial effect; lavender oil was screened against bacteria obtained from swab specimen of human subjects' RAU using disc diffusion method. Fourthly, clinical study; 115 subjects (mean age 38 years, mean weight 75 kg) were divided into two groups of subjects topically treated with lavender oil or placebo. The clinical efficacy was assessed by inflammation level, erythema, edema, ulcer duration, ulcer size, mean area under the curve of ulcer area, healing time, and associated pain intensity and reduction.
Results: Animals treated with lavender oil showed a significant ulcer size reduction, increased rate of mucosal repair, and healing within 3 days of treatment compared to baseline and placebo groups [2-3 days (90%), 4 days (10%)] (P=0.001). The intraperitoneal LD50 value in mice was 6.5 gm/kg; clinical dermal irritation test showed no sign of irritation in the tested products. Lavender oil showed a broad antibacterial activity against all tested strains; it exhibited significant inhibition on tested bacteria where the value of zone of inhibition ranged from 14.5-24 mm vs Streptomycin (25 microg/disc) 12-22 +/- 0.5 mm; MIC was > 6.4-36 mg/ml. RAU patients treated with lavender oil showed a significant reduction in inflammation level, ulcer size, healing time, from 2-4 days [2 days (40%), 3 days (50%), 4 days (10%)], and pain relief mostly from the first dose, compared to baseline and placebo. No side effects were reported.
Comment in
-
There is limited evidence that topical lavender oil is effective for palliative treatment of recurrent aphthous stomatitis.J Evid Based Dent Pract. 2013 Jun;13(2):47-9. doi: 10.1016/j.jebdp.2013.04.012. J Evid Based Dent Pract. 2013. PMID: 23773464 No abstract available.
Similar articles
-
There is limited evidence that topical lavender oil is effective for palliative treatment of recurrent aphthous stomatitis.J Evid Based Dent Pract. 2013 Jun;13(2):47-9. doi: 10.1016/j.jebdp.2013.04.012. J Evid Based Dent Pract. 2013. PMID: 23773464 No abstract available.
-
Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of 'subsyndromal' anxiety disorder: a randomized, double-blind, placebo controlled trial.Int Clin Psychopharmacol. 2010 Sep;25(5):277-87. doi: 10.1097/YIC.0b013e32833b3242. Int Clin Psychopharmacol. 2010. PMID: 20512042 Clinical Trial.
-
The Effects of Lavender Essential Oil on Wound Healing: A Review of the Current Evidence.J Altern Complement Med. 2020 Aug;26(8):680-690. doi: 10.1089/acm.2019.0286. Epub 2020 Jun 24. J Altern Complement Med. 2020. PMID: 32589447 Review.
-
Wound healing potential of lavender oil by acceleration of granulation and wound contraction through induction of TGF-β in a rat model.BMC Complement Altern Med. 2016 May 26;16:144. doi: 10.1186/s12906-016-1128-7. BMC Complement Altern Med. 2016. PMID: 27229681 Free PMC article.
-
Myrtus communis L. and its application in treatment of Recurrent Aphthous Stomatitis.J Ethnopharmacol. 2016 Dec 4;193:481-489. doi: 10.1016/j.jep.2016.09.054. Epub 2016 Sep 30. J Ethnopharmacol. 2016. PMID: 27693775 Review.
Cited by
-
Multiplicative Effects of Essential Oils and Other Active Components on Skin Tissue and Skin Cancers.Int J Mol Sci. 2024 May 15;25(10):5397. doi: 10.3390/ijms25105397. Int J Mol Sci. 2024. PMID: 38791435 Free PMC article. Review.
-
The effect of topically administered lavender aromatherapy on the pain of insulin injection in diabetic patients: a double-blind randomized controlled clinical trial.Turk J Med Sci. 2022 Dec;52(6):1845-1853. doi: 10.55730/1300-0144.5531. Epub 2022 Dec 21. Turk J Med Sci. 2022. PMID: 36945997 Free PMC article. Clinical Trial.
-
Brazilian essential oils as source for the discovery of new anti-COVID-19 drug: a review guided by in silico study.Phytochem Rev. 2021;20(5):1013-1032. doi: 10.1007/s11101-021-09754-4. Epub 2021 Apr 13. Phytochem Rev. 2021. PMID: 33867898 Free PMC article. Review.
-
Using Medicinal Plants in Valmalenco (Italian Alps): From Tradition to Scientific Approaches.Molecules. 2020 Sep 10;25(18):4144. doi: 10.3390/molecules25184144. Molecules. 2020. PMID: 32927742 Free PMC article.
-
Ferulic Acid-NLC with Lavandula Essential Oil: A Possible Strategy for Wound-Healing?Nanomaterials (Basel). 2020 May 8;10(5):898. doi: 10.3390/nano10050898. Nanomaterials (Basel). 2020. PMID: 32397093 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Medical