Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
- PMID: 22446882
- PMCID: PMC3380241
- DOI: 10.1038/nn.3079
Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche
Abstract
Adult hypothalamic neurogenesis has recently been reported, but the cell of origin and the function of these newborn neurons are unknown. Using genetic fate mapping, we found that median eminence tanycytes generate newborn neurons. Blocking this neurogenesis altered the weight and metabolic activity of adult mice. These findings reveal a previously unreported neurogenic niche in the mammalian hypothalamus with important implications for metabolism.
Figures
![Figure 1](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59fd/3380241/7d7eaf06dace/nihms360926f1.gif)
![Figure 2](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59fd/3380241/6cbbdbf07074/nihms360926f2.gif)
![Figure 3](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/59fd/3380241/b2da97a36102/nihms360926f3.gif)
Comment in
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Fat incites tanycytes to neurogenesis.Nat Neurosci. 2012 Apr 25;15(5):651-3. doi: 10.1038/nn.3091. Nat Neurosci. 2012. PMID: 22534576 No abstract available.
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