Peroxisome proliferator-activated receptor gamma (PPAR-γ) and neurodegenerative disorders
- PMID: 22434581
- DOI: 10.1007/s12035-012-8259-8
Peroxisome proliferator-activated receptor gamma (PPAR-γ) and neurodegenerative disorders
Abstract
As the growth of the aging population continues to accelerate globally, increased prevalence of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and stroke, has generated substantial public concern. Unfortunately, despite of discoveries of common factors underlying these diseases, few drugs are available to effectively treat these diseases. Peroxisome proliferator-activated receptor gamma (PPAR-γ) is a ligand-activated transcriptional factor that belongs to the nuclear hormone receptor superfamily. PPAR-γ has been shown to influence the expression or activity of a large number of genes in a variety of signaling networks, including regulation of insulin sensitivity, glucose homeostasis, fatty acid oxidation, immune responses, redox balance, cardiovascular integrity, and cell fates. Recent epidemiological, preclinical animal, and clinical studies also show that PPAR-γ agonists can lower the incidence of a number of neurological disorders, despite of multiple etiological factors involved in the development of these disorders. In this manuscript, we review current knowledge on mechanisms underlying the beneficial effect of PPAR-γ in different neurodegenerative diseases, in particular, AD, PD, and stroke, and attempt to analyze common and overlapping features among these diseases. Our investigation unveiled information suggesting the ability for PPAR-γ to inhibit NF-κB-mediated inflammatory signaling at multiple sites, and conclude that PPAR-γ agonists represent a novel class of drugs for treating neuroinflammatory diseases.
Similar articles
-
PPARγ and PGC-1α as therapeutic targets in Parkinson's.Neurochem Res. 2015 Feb;40(2):308-16. doi: 10.1007/s11064-014-1377-0. Epub 2014 Jul 10. Neurochem Res. 2015. PMID: 25007880 Free PMC article. Review.
-
Minutes of PPAR-γ agonism and neuroprotection.Neurochem Int. 2020 Nov;140:104814. doi: 10.1016/j.neuint.2020.104814. Epub 2020 Aug 3. Neurochem Int. 2020. PMID: 32758586 Review.
-
Peroxisome proliferator-activated receptor-γ cofactors in neurodegeneration.IUBMB Life. 2012 Dec;64(12):958-64. doi: 10.1002/iub.1097. Epub 2012 Nov 6. IUBMB Life. 2012. PMID: 23129362 Review.
-
Peroxisome proliferator-activated receptor (PPAR)β/δ, a possible nexus of PPARα- and PPARγ-dependent molecular pathways in neurodegenerative diseases: Review and novel hypotheses.Neurochem Int. 2013 Oct;63(4):322-30. doi: 10.1016/j.neuint.2013.06.012. Epub 2013 Jun 25. Neurochem Int. 2013. PMID: 23811400 Review.
-
G Protein-coupled Receptor 40 (GPR40) and Peroxisome Proliferator-activated Receptor γ (PPARγ): AN INTEGRATED TWO-RECEPTOR SIGNALING PATHWAY.J Biol Chem. 2015 Aug 7;290(32):19544-57. doi: 10.1074/jbc.M115.638924. Epub 2015 Jun 23. J Biol Chem. 2015. PMID: 26105050 Free PMC article.
Cited by
-
Rosiglitazone Promotes White Matter Integrity and Long-Term Functional Recovery After Focal Cerebral Ischemia.Stroke. 2015 Sep;46(9):2628-36. doi: 10.1161/STROKEAHA.115.010091. Epub 2015 Aug 4. Stroke. 2015. PMID: 26243225 Free PMC article.
-
Role of miRNAs in Alzheimer's Disease and Possible Fields of Application.Int J Mol Sci. 2019 Aug 15;20(16):3979. doi: 10.3390/ijms20163979. Int J Mol Sci. 2019. PMID: 31443326 Free PMC article. Review.
-
Inhibition of miR-128 Abates Aβ-Mediated Cytotoxicity by Targeting PPAR-γ via NF-κB Inactivation in Primary Mouse Cortical Neurons and Neuro2a Cells.Yonsei Med J. 2018 Nov;59(9):1096-1106. doi: 10.3349/ymj.2018.59.9.1096. Yonsei Med J. 2018. PMID: 30328325 Free PMC article.
-
Exploring the role of COX-2 in Alzheimer's disease: Potential therapeutic implications of COX-2 inhibitors.Saudi Pharm J. 2023 Sep;31(9):101729. doi: 10.1016/j.jsps.2023.101729. Epub 2023 Aug 7. Saudi Pharm J. 2023. PMID: 37638222 Free PMC article. Review.
-
Thermodynamics in Neurodegenerative Diseases: Interplay Between Canonical WNT/Beta-Catenin Pathway-PPAR Gamma, Energy Metabolism and Circadian Rhythms.Neuromolecular Med. 2018 Jun;20(2):174-204. doi: 10.1007/s12017-018-8486-x. Epub 2018 Mar 23. Neuromolecular Med. 2018. PMID: 29572723 Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials