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. 2012 Apr;6(3):362-7.
doi: 10.1016/j.crohns.2011.10.003. Epub 2011 Nov 10.

Portal vein thrombosis in inflammatory bowel diseases: a single-center case series

Giovanni Maconi  1 , Elena Bolzacchini, Alessandra Dell'Era, Umberto Russo, Sandro Ardizzone, Roberto de Franchis
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Portal vein thrombosis in inflammatory bowel diseases: a single-center case series

Giovanni Maconi et al. J Crohns Colitis. 2012 Apr.

Abstract

Background and methods: Portal vein thrombosis (PVT) has been reported as a complication of IBD in some case reports. We describe the presentation, diagnostic approaches, underlying risks factors and clinical outcome of 8 IBD patients with PVT. CASE-SERIES: The patients presented with partial PVT (4 patients) or portal cavernoma. Five patients had undergone surgery. In 2 patients portal biliopathy was diagnosed after detection of PVT. In 4 patients, the diagnosis of PVT was made while IBD was in remission. Five patients showed at least one risk factor for hypercoagulability: lupus anti-coagulant (one patient), increased von Willebrand factor (2 patients) or homocysteine levels (4 patients). Four patients received anticoagulant therapy for 6 months. None experienced other thrombotic events during a median of 5 years (range 2-8 years).

Conclusion: PVT is a potential complication of IBD, usually associated with acquired or inherited risks factors for hypercoagulability and with a benign outcome.

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