Cross-talk between AMPK and mTOR in regulating energy balance
- PMID: 22369257
- DOI: 10.1080/10408398.2010.500245
Cross-talk between AMPK and mTOR in regulating energy balance
Abstract
Energy balance is maintained by a complex homeostatic system involving some signaling pathways and "nutrient sensors" in multiple tissues and organs. Any defect associated with the pathways can lead to metabolic disorders including obesity, type 2 diabetes, and the metabolic syndrome. The 5'-adenosine monophosphate-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) appear to play a significant role in the intermediary metabolism of these diseases. AMPK is involved in the fundamental regulation of energy balance at the whole body level by responding to hormonal and nutrient signals in the central nervous system and peripheral tissues that modulate food intake and energy expenditure. Mammalian target of rapamycin (mTOR),is one of the downstream targets of AMPK functions as an intracellular nutrient sensor to control protein synthesis, cell growth, and metabolism. Recent research demonstrated the possible interplay between mTOR and AMPK signaling pathways. In this review, we will present current knowledge of AMPK and mTOR pathways in regulating energy balance and demonstrate the convergence between these two pathways.
Similar articles
-
Role of energy- and nutrient-sensing kinases AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in adipocyte differentiation.IUBMB Life. 2013 Jul;65(7):572-83. doi: 10.1002/iub.1170. Epub 2013 May 14. IUBMB Life. 2013. PMID: 23671028 Review.
-
PAS kinase is a nutrient and energy sensor in hypothalamic areas required for the normal function of AMPK and mTOR/S6K1.Mol Neurobiol. 2014 Oct;50(2):314-26. doi: 10.1007/s12035-013-8630-4. Epub 2014 Jan 21. Mol Neurobiol. 2014. PMID: 24445950
-
Effects of AMP-activated protein kinase (AMPK) signaling and essential amino acids on mammalian target of rapamycin (mTOR) signaling and protein synthesis rates in mammary cells.J Dairy Sci. 2014;97(1):419-29. doi: 10.3168/jds.2013-7189. Epub 2013 Nov 1. J Dairy Sci. 2014. PMID: 24183687
-
Hypothalamic mTOR: the rookie energy sensor.Curr Mol Med. 2014 Jan;14(1):3-21. doi: 10.2174/1566524013666131118103706. Curr Mol Med. 2014. PMID: 24236459 Review.
-
Stimulation of cardiomyogenesis of embryonic stem cells by nitric oxide downstream of AMP-activated protein kinase and mTOR signaling pathways.Stem Cells Dev. 2011 Dec;20(12):2163-75. doi: 10.1089/scd.2010.0581. Epub 2011 Apr 6. Stem Cells Dev. 2011. PMID: 21470048
Cited by
-
Butyrate reduces cellular magnesium absorption independently of metabolic regulation in Caco-2 human colon cells.Sci Rep. 2022 Nov 3;12(1):18551. doi: 10.1038/s41598-022-21683-6. Sci Rep. 2022. PMID: 36329098 Free PMC article.
-
Diabetic peripheral neuropathy: pathogenetic mechanisms and treatment.Front Endocrinol (Lausanne). 2024 Jan 9;14:1265372. doi: 10.3389/fendo.2023.1265372. eCollection 2023. Front Endocrinol (Lausanne). 2024. PMID: 38264279 Free PMC article. Review.
-
Milk--A Nutrient System of Mammalian Evolution Promoting mTORC1-Dependent Translation.Int J Mol Sci. 2015 Jul 27;16(8):17048-87. doi: 10.3390/ijms160817048. Int J Mol Sci. 2015. PMID: 26225961 Free PMC article. Review.
-
ATF4/TXNIP/REDD1/mTOR signaling mediates the antitumor activities of liver X receptor in pancreatic cancers.Cancer Innov. 2022 Jun 30;1(1):55-69. doi: 10.1002/cai2.12. eCollection 2022 Jun. Cancer Innov. 2022. PMID: 38089448 Free PMC article.
-
Liraglutide attenuates obese-associated breast cancer cell proliferation via inhibiting PI3K/Akt/mTOR signaling pathway.Saudi Pharm J. 2024 Jan;32(1):101923. doi: 10.1016/j.jsps.2023.101923. Epub 2023 Dec 18. Saudi Pharm J. 2024. PMID: 38223522 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
