Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jan;29(1):44-9.
doi: 10.4103/0970-2113.92361.

Pulmonary drug delivery strategies: A concise, systematic review

J S Patil  1 , S Sarasija
Affiliations

Pulmonary drug delivery strategies: A concise, systematic review

J S Patil et al. Lung India. 2012 Jan.

Abstract

Because of limitations associated with the conventional treatment of various chronic diseases a growing attention has been given to the development of targeted drug delivery systems. Pulmonary route of drug delivery gaining much importance in the present day research field as it enables to target the drug delivery directly to lung both for local and systemic treatment. Over the last 2 decades, the systemic absorption of a broad range of therapeutics after pulmonary application has been demonstrated in animals as well as in humans. This review was prepared with an aim to discuss the technical, physiological, and efficacy aspects of the novel pulmonary route of drug targeting. The review also focuses on the mechanisms of pulmonary drug administration along with compatibility of the excipients employed, devices used, and techniques of particulate dosage production. This review was prepared based on the method of extensive literature survey on the topics covering all the aspects discussed in the present subject. Hence, the better understanding of complexes and challenges facing the development of pulmonary drug delivery system offer an opportunity to the pharmaceutical scientist in minimizing the clinical and technical gaps.

Keywords: Dry powder inhaler; lung deposition; pulmonary route; targeted drug delivery.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: None declared.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Groneberg DA, Nickolaus M, Spinger J, Doring F, Daniel H, Fischer A. Localization of peptide transporter PEPT2 in the lung: implications of pulmonary oligopeptide uptake. Am J Pathol. 2001;158:707–14. - PMC - PubMed
    1. Groneberg DA, Eynott PR, Döring F, Dinh QT, Oates T, Barnes PJ, et al. Distribution and function of the peptide transporter PEPT2 in normal and cystic fibrosis human lung. Thorax. 2002;57:55–60. - PMC - PubMed
    1. Groneberg DA, Witt C, Wagner U, Chung KF, Fischer A. Fundamentals of pulmonary drug delivery. Resp Med. 2003;97:382–87. - PubMed
    1. Tuncer DI, Nevin C. Controlled Delivery of Peptides and Proteins. Curr Pharm Des. 2007;13:99–117. - PubMed
    1. Sangwan S, Agosti JM, Bauer LA, Otulana BA, Morishige RJ, Cipolla DC, et al. Aerozolized protein delivery in asthma: Gamma camera analysis of regional deposition and perfusion. J Aerosol Med. 2001;14:185–95. - PubMed