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Case Reports
. 2012 May;26(5):759-60.
doi: 10.1038/eye.2012.17. Epub 2012 Feb 10.

Cytomegalovirus retinitis successfully treated with ganciclovir implant in a patient with blood ganciclovir resistance and ocular ganciclovir sensitivity

N K Bakshi, G A Fahle, I Sereti, H Wiley, R B Nussenblatt, H N Sen
Case Reports

Cytomegalovirus retinitis successfully treated with ganciclovir implant in a patient with blood ganciclovir resistance and ocular ganciclovir sensitivity

N K Bakshi et al. Eye (Lond). 2012 May.
No abstract available

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Figures

Figure 1
Figure 1
CMV retinitis treated with GCV implant. Fundus photograph of the right (a) and left (b) eye at presentation, with large areas of CMV retinitis and necrosis in the peripheral and mid-peripheral retina. In the left eye, the CMV retinitis is in close proximity to the optic nerve and an inferonasal branch retinal artery occlusion was observed. The right eye also has a long-standing full thickness macular hole. At 1 year following injection of intravitreal Foscarnet and GCV in both eyes and insertion of the GCV implant in the left eye, both eyes remain free of CMV retinitis (c, d). Pigmentary changes are noted at the site of prior retinitis. The GCV implant remains sutured in place at pars plana (e).
Figure 2
Figure 2
GCV resistance sequencing. Detection of methionine to valine mutation at codon 460 (M460V), in the UL97 phosphotransferase gene in the PB (fourth panel) but not the ocular specimen (first panel) is shown. Note the change in peak from sensitive to resistant with time (second through fourth panels).
See this image and copyright information in PMC

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