Increased miR-222 in H. pylori-associated gastric cancer correlated with tumor progression by promoting cancer cell proliferation and targeting RECK
- PMID: 22321642
- DOI: 10.1016/j.febslet.2012.01.025
Increased miR-222 in H. pylori-associated gastric cancer correlated with tumor progression by promoting cancer cell proliferation and targeting RECK
Abstract
Little is known about the potential role of microRNAs (miRNAs) in the carcinogenesis of gastric cancer induced by Helicobacter pylori (H. pylori). Here, we showed that microRNA-222 (miR-222) was up-regulated in H. pylori-infected gastric mucosa and gastric cancer. Ectopic expression of miR-222 promoted cell proliferation and colony formation in vitro. Mechanistically, we identified RECK as a novel target of miR-222, and also confirmed their relationship by the inverse correlation of mRNA expression ex vivo. Furthermore, we found that RNA interference silencing of RECK can mimic the oncogenic effects of miR-222. Collectively, H. pylori may function as an initiator in the process of carcinogenesis by up-regulating miR-222, which further participates in the progression of cancer by promoting proliferation and inhibiting RECK.
Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Similar articles
-
Reduced microRNA-218 expression is associated with high nuclear factor kappa B activation in gastric cancer.Cancer. 2010 Jan 1;116(1):41-9. doi: 10.1002/cncr.24743. Cancer. 2010. PMID: 19890957
-
Helicobacter pylori and gastric cancer: possible role of microRNAs in this intimate relationship.Clin Microbiol Infect. 2009 Sep;15(9):806-12. doi: 10.1111/j.1469-0691.2009.02960.x. Clin Microbiol Infect. 2009. PMID: 19702585 Review.
-
Increased miR-146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis.Oncol Rep. 2012 Feb;27(2):559-66. doi: 10.3892/or.2011.1514. Epub 2011 Oct 21. Oncol Rep. 2012. PMID: 22020746
-
miR-221 and miR-222 Simultaneously Target RECK and Regulate Growth and Invasion of Gastric Cancer Cells.Med Sci Monit. 2015 Sep 13;21:2718-25. doi: 10.12659/MSM.894324. Med Sci Monit. 2015. PMID: 26364844 Free PMC article.
-
Apoptosis in gastric epithelium induced by Helicobacter pylori infection: implications in gastric carcinogenesis.Am J Gastroenterol. 2001 Jan;96(1):16-26. doi: 10.1111/j.1572-0241.2001.03447.x. Am J Gastroenterol. 2001. PMID: 11197247 Review.
Cited by
-
Direct targeting of HGF by miR-16 regulates proliferation and migration in gastric cancer.Tumour Biol. 2016 Nov;37(11):15175-15183. doi: 10.1007/s13277-016-5390-6. Epub 2016 Sep 28. Tumour Biol. 2016. PMID: 27683052
-
Potential Diagnostic, Prognostic and Therapeutic Targets of MicroRNAs in Human Gastric Cancer.Int J Mol Sci. 2016 Jun 16;17(6):945. doi: 10.3390/ijms17060945. Int J Mol Sci. 2016. PMID: 27322246 Free PMC article. Review.
-
MiR-96 downregulates RECK to promote growth and motility of non-small cell lung cancer cells.Mol Cell Biochem. 2014 May;390(1-2):155-60. doi: 10.1007/s11010-014-1966-x. Epub 2014 Jan 29. Mol Cell Biochem. 2014. PMID: 24469470
-
MiR-374b-5p suppresses RECK expression and promotes gastric cancer cell invasion and metastasis.World J Gastroenterol. 2014 Dec 14;20(46):17439-47. doi: 10.3748/wjg.v20.i46.17439. World J Gastroenterol. 2014. PMID: 25516656 Free PMC article.
-
A microRNA 221- and 222-mediated feedback loop maintains constitutive activation of NFκB and STAT3 in colorectal cancer cells.Gastroenterology. 2014 Oct;147(4):847-859.e11. doi: 10.1053/j.gastro.2014.06.006. Epub 2014 Jun 12. Gastroenterology. 2014. PMID: 24931456 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases
