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Review
. 2012 Mar;12(3):259-67.
doi: 10.2174/156652412799218903.

The PD-1/PD-L1 pathway in human pathology

M Saresella  1 , V Rainone, N M Al-Daghri, M Clerici, D Trabattoni
Affiliations
Review

The PD-1/PD-L1 pathway in human pathology

M Saresella et al. Curr Mol Med. 2012 Mar.

Abstract

T-cell activation is dependent on signals delivered through the antigen-specific T-cell receptor and accessory receptors on T-cells. Integration of signals through this family of costimulatory and inhibitory receptors and their ligands regulates the balance between T-cell activation, tolerance, and immunopathology. Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, deliver inhibitory signals and exert a vital and diverse range of immunoregulatory roles in T-cell activation, tolerance, and immune-mediated tissue damage. In this review, we revisit current understanding of the immunoregulatory functions of PD-1 and its ligands and their involvement in immune-mediated diseases.

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