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. 2012 Mar;142(3):390-8.
doi: 10.1016/j.clim.2012.01.002. Epub 2012 Jan 14.

IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE

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IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE

Caroline Grönwall et al. Clin Immunol. 2012 Mar.

Abstract

Emerging evidence suggests that there are IgM-autoantibodies that may play protective roles in SLE. While IgM are often considered polyreactive, we postulate that there are distinct sets of IgM-autoantibodies of defined autoreactive specificities relevant to different features of SLE. We examined the relationships between levels of IgM natural autoantibodies (NAbs) to apoptosis-associated phosphorylcholine (PC) or malondialdehyde (MDA) antigens, with lupus-associated autoantibodies and features of disease, in 120 SLE patients. IgM anti-PC was significantly higher in patients with low disease activity and less organ damage determined by the SELENA-SLEDAI, the physician's evaluation and the SLICC damage score. Furthermore, IgM anti-PC was significantly higher in patients without cardiovascular events. In contrast, IgM anti-cardiolipin and IgM anti-dsDNA were significantly higher in patients without renal disease. These results support the hypothesis that some IgM autoantibodies are part of a natural immune repertoire that provide homeostatic functions and protection from certain clinical lupus features.

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Figures

Figure 1
Figure 1
Correlations between anti-PC and anti-MDA autoantibody levels with the SLEDAI or SLICC scores. Analyses were performed by Spearman's rank correlations, and significant associations are indicated.
Figure 2
Figure 2
IgM-autoantibody levels and the presence or the absence of renal involvement or ASCVD events. Healthy n=28, anti-PC, anti-MDA patients with renal disease n=27, patients without renal disease n=93, patients with ASCVD event n=25, patients without ASCVD event n=95. For anti-β2-GPI, -CL, and anti-dsDNA: patients with renal disease n=25, patients without renal disease n=70, patients with ASCVD event n=23, patients without ASCVD n=78. In some cases the amount of sample was not adequate for all tests. p-Values were determined with two-sided Mann–Whitney non-parametric testing, with significant values indicated.

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