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. 2012 Mar;27(3):406-12.
doi: 10.1002/mds.24892. Epub 2012 Jan 11.

Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome Study

Andrew Siderowf  1 , Danna Jennings, Shirley Eberly, David Oakes, Keith A Hawkins, Albert Ascherio, Matthew B Stern, Kenneth Marek; PARS Investigators
Collaborators, Affiliations

Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome Study

Andrew Siderowf et al. Mov Disord. 2012 Mar.

Abstract

To test the association between impaired olfaction and other prodromal features of PD in the Parkinson At-Risk Syndrome Study. The onset of olfactory dysfunction in PD typically precedes motor features, suggesting that olfactory testing could be used as a screening test. A combined strategy that uses other prodromal nonmotor features, along with olfactory testing, may be more efficient than hyposmia alone for detecting the risk of PD. Individuals with no neurological diagnosis completed a mail survey, including the 40-item University of Pennsylvania Smell Identification Test, and questions on prodromal features of PD. The frequency of reported nonmotor features was compared across individuals with and without hyposmia. A total of 4,999 subjects completed and returned the survey and smell test. Of these, 669 were at or below the 15th percentile based on age and gender, indicating hyposmia. Hyposmics were significantly more likely to endorse nonmotor features, including anxiety and depression, constipation, and rapid eye movement sleep behavior disorder symptoms, and to report changes in motor function. Twenty-six percent of subjects with combinations of four or more nonmotor features were hyposmic, compared to 12% for those reporting three or fewer nonmotor features (P < 0.0001). Hyposmia is associated with other nonmotor features of PD in undiagnosed individuals. Further assessment of hyposmic subjects using more specific markers for degeneration, such as dopamine transporter imaging, will evaluate whether combining hyposmia and other nonmotor features is useful in assessing the risk of future neurodegeneration.

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Figures

FIG. 1.
FIG. 1.
Flow diagram of ascertainment of study cohort. Reasons for ineligibility are given in the text.
FIG. 2.
FIG. 2.
Proportion of individuals with hyposmia in subjects with combinations of prodromal features. Prodromal features included the following: (1) having any RBD symptom at least once a month; (2) endorsing two or more items on the PD symptom self-report questionnaire; (3) having a CES-D score of greater than 15; (4) having a STAI-A or -B score of >39; or (5) having bowel movement frequency of <1 per day. Individuals with higher numbers of prodromal features, particularly four or five, are more likely to be hyposmic (P <0.0001).
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References

    1. Morrish PK, Rakshi JS, Bailey DL, Sawle GV, Brooks DJ. Measuring the rate of progression and estimating the preclinical period of Parkinson’s disease with [18F]dopa PET. J Neurol Neurosurg Psychiatry 1998;64:314–319. - PMC - PubMed
    1. Varrone A, Marek KL, Jennings D, Innis RB, Seibyl JP. [(123)I]beta-CIT SPECT imaging demonstrates reduced density of striatal dopamine transporters in Parkinson’s disease and multiple system atrophy. Mov Disord 2001;16:1023–1032. - PubMed
    1. Gonera EG, Van’t Hof M, Berger HJC, Van Weel C, Horstink WIM. Symptoms and duration of the prodromal phase in Parkinson’s disease. Mov Disord 1997;12:871–876. - PubMed
    1. Stern MB. The preclinical detection of Parkinson’s disease: ready for prime time? Ann Neurol 2004;56:169–171. - PubMed
    1. Stern MB, Doty RL, Dotti M, et al. Olfactory function in Parkinson’s disease subtypes. Neurology 1994;44:266–268. - PubMed