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Review
. 2012 Feb;33(2):84-90.
doi: 10.1016/j.it.2011.11.005. Epub 2012 Jan 3.

Memory T cell inflation: understanding cause and effect

Geraldine A O'Hara  1 , Suzanne P M Welten, Paul Klenerman, Ramon Arens
Affiliations
Review

Memory T cell inflation: understanding cause and effect

Geraldine A O'Hara et al. Trends Immunol. 2012 Feb.

Abstract

Typically, during viral infections, T cells encounter antigen, undergo proliferative expansion and ultimately contract into a pool of memory cells. However, after infection with cytomegalovirus, a ubiquitous β-herpesvirus, T cell populations specific for certain epitopes do not contract but instead are maintained and/or accumulate at high frequencies with a characteristic effector-memory phenotype. This feature has also been noted after other infections, for example, by parvoviruses. We discuss this so-called memory T cell inflation and the factors involved in this phenomenon. Also, we consider the potential therapeutic use of memory T cell inflation as a vaccine strategy and the associated implications for immune senescence.

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