Acidic bone matrix proteins and their roles in calcification
- PMID: 22201843
- DOI: 10.2741/4026
Acidic bone matrix proteins and their roles in calcification
Abstract
Mammalian bones are composed of calcium phosphate crystals in a protein matrix. The major form of the calcium phosphate is hydroxyapatite. The most abundant matrix protein in bone is type I collagen. Collagen contributes to the mechanical properties of bone and is necessary for calcification of the tissue. In addition to collagen, several acidic proteins are present as minor components. Osteocalcin is a gamma-carboxyglutamic acid-containing protein of bone, which has an affinity to hydroxyapatite and can prevent crystal growth. Bone sialoprotein (BSP) and osteopontin are acidic glycophosphoproteins of bone. These proteins have RGD cell-attachment sequences and consecutive sequences of acidic amino acids. The poly glutamic acid sequences of BSP act as possible nucleation sites for hydroxyapatite crystals. Dentin phosphoprotein is the major non-collagenous protein of dentin. This protein has (Asp-Ser-Ser) repeat sequences, in which most of the Ser residues are phosphorylated. Some of these acidic matrix proteins are immobilized on the collagen fibrils and induce nucleation of hydroxyapatite crystals. They can also modulate crystal shape by adsorption on a specific face of the crystals.
Similar articles
-
Vertebrate mineralized matrix proteins: structure and function.Connect Tissue Res. 1996;35(1-4):131-6. doi: 10.3109/03008209609029183. Connect Tissue Res. 1996. PMID: 9084650 Review.
-
Why does bone matrix contain non-collagenous proteins? The possible roles of osteocalcin, osteonectin, osteopontin and bone sialoprotein in bone mineralisation and resorption.Cell Biol Int. 1994 Jun;18(6):617-28. doi: 10.1006/cbir.1994.1088. Cell Biol Int. 1994. PMID: 8075622
-
Is all bone the same? Distinctive distributions and properties of non-collagenous matrix proteins in lamellar vs. woven bone imply the existence of different underlying osteogenic mechanisms.Crit Rev Oral Biol Med. 1998;9(2):201-23. doi: 10.1177/10454411980090020401. Crit Rev Oral Biol Med. 1998. PMID: 9603236 Review.
-
Mineral-matrix interactions in bone and dentin.J Bone Miner Res. 1993 Dec;8 Suppl 2:S493-7. doi: 10.1002/jbmr.5650081312. J Bone Miner Res. 1993. PMID: 8122518 Review.
-
Expression of bone matrix proteins associated with mineralized tissue formation by adult rat bone marrow cells in vitro: inductive effects of dexamethasone on the osteoblastic phenotype.J Cell Physiol. 1991 Apr;147(1):111-20. doi: 10.1002/jcp.1041470115. J Cell Physiol. 1991. PMID: 2037618
Cited by
-
24R,25-dihydroxyvitamin D3 promotes the osteoblastic differentiation of human mesenchymal stem cells.Mol Endocrinol. 2014 May;28(5):644-58. doi: 10.1210/me.2013-1241. Epub 2014 Mar 5. Mol Endocrinol. 2014. PMID: 24597546 Free PMC article.
-
New methods to study the composition and structure of the extracellular matrix in natural and bioengineered tissues.Biomatter. 2012 Jul-Sep;2(3):115-31. doi: 10.4161/biom.20866. Biomatter. 2012. PMID: 23507863 Free PMC article. Review.
-
Support of bone mineral deposition by regulation of pH.Am J Physiol Cell Physiol. 2018 Oct 1;315(4):C587-C597. doi: 10.1152/ajpcell.00056.2018. Epub 2018 Jul 25. Am J Physiol Cell Physiol. 2018. PMID: 30044661 Free PMC article.
-
Cellular and extracellular matrix of bone, with principles of synthesis and dependency of mineral deposition on cell membrane transport.Am J Physiol Cell Physiol. 2020 Jan 1;318(1):C111-C124. doi: 10.1152/ajpcell.00120.2019. Epub 2019 Sep 18. Am J Physiol Cell Physiol. 2020. PMID: 31532718 Free PMC article. Review.
-
Calcinosis Biomarkers in Adult and Juvenile Dermatomyositis.Autoimmun Rev. 2020 Jun;19(6):102533. doi: 10.1016/j.autrev.2020.102533. Epub 2020 Mar 28. Autoimmun Rev. 2020. PMID: 32234404 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Research Materials
