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. 2012 Aug;112(8):3173-7.
doi: 10.1007/s00421-011-2287-3. Epub 2011 Dec 23.

Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise

Cécile Jamart  1 , Nicolas Benoit, Jean-Marc Raymackers, Hyo Jeong Kim, Chang Keun Kim, Marc Francaux
Affiliations

Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise

Cécile Jamart et al. Eur J Appl Physiol. 2012 Aug.

Abstract

The purpose of this study was to evaluate whether ultra endurance exercise changes the mRNA levels of the autophagy-related and autophagy-regulatory genes. Eight men (44 ± 1 years, range: 38-50 years) took part in a 200-km running race. The average running time was 28 h 03 min ± 2 h 01 min (range: 22 h 15 min-35 h 04 min). A muscle sample was taken from the vastus lateralis 2 weeks prior to the race and 3 h after arrival. Gene expression was assessed by RT-qPCR. Transcript levels of autophagy-related genes were increased by 49% for ATG4b (P = 0.025), 57% for ATG12 (P = 0.013), 286% for Gabarapl1 (P = 0.008) and 103% for LC3b (P = 0.011). The lysosomal enzyme cathepsin L mRNA was upregulated by 123% (P = 0.003). Similarly, transcript levels of the autophagy-regulatory genes BNIP3 and BNIP3l were both increased by 113% (P = 0.031 and P = 0.007, respectively). Since upregulation of these genes has been related with an increased autophagic flux in various models, our results strongly suggest that autophagy is activated in response to ultra endurance exercise.

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