doi: 10.1016/j.bmcl.2011.11.019.
Epub 2011 Nov 12.
Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases
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- PMID: 22153662
- DOI: 10.1016/j.bmcl.2011.11.019
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Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases
Bioorg Med Chem Lett.
.
Abstract
A new series of Quinazoline Ether Inhibitor which potently inhibits VEGFR-2 and PDGFR tyrosine kinases is described here. In vitro, pharmacokinetics and in vivo evaluations led to the selection of AZD2932.
Copyright © 2011 Elsevier Ltd. All rights reserved.
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