Antidiabetes drugs correlate with decreased risk of lung cancer: a population-based observation in Taiwan
- PMID: 22129971
- DOI: 10.1016/j.cllc.2011.10.002
Antidiabetes drugs correlate with decreased risk of lung cancer: a population-based observation in Taiwan
Abstract
Background: The risk of some forms of cancer has been found to be higher in patients with diabetes mellitus (DM) than in the general population. The aim of this study was to examine, with sufficient statistical power, the association between DM and lung cancer and the impact of antidiabetes drugs on lung cancer risk in Taiwan.
Materials and methods: From a randomly selected data set of 1 million National Health Insurance (NHI) claims in Taiwan from 2000-2005, 19,624 cases (patients ≥ 20 years of age) of newly diagnosed DM were identified. From the same data set, 78,496 enrollees with no record of DM were selected as controls and were matched in sex and age to the first group. The incidence of newly diagnosed lung cancer was compared between patients with DM and controls for a period of 9 years (2000-2008).
Results: The multivariate Cox model analysis showed a slightly increased hazard ratio (HR) of 1.05 of lung cancer in patients with DM, but the association was not statistically significant. However the use of antidiabetes drugs, such as metformin, thiazolidinediones, or alpha-glucosidase inhibitors, correlates with a decreased lung cancer risk of 39%-45%. A significant association was found between lung cancer risk and male sex (HR, 2.23), pulmonary tuberculosis (HR, 1.60), chronic obstructive pulmonary disease (HR, 1.21), and age (HR, 1.07).
Conclusion: Patients with DM are not at increased risk for the development of lung cancer, but the use of antidiabetes drugs would considerably decrease the risk. In this cohort, male sex, age, pulmonary tuberculosis, and chronic obstructive pulmonary disease were all associated with an increased risk of lung cancer, consistent with findings in the literature and indicative of the validity of our study.
Copyright © 2012 Elsevier Inc. All rights reserved.
Similar articles
-
Risk of acute pancreatitis in type 2 diabetes and risk reduction on anti-diabetic drugs: a population-based cohort study in Taiwan.Am J Gastroenterol. 2011 Sep;106(9):1697-704. doi: 10.1038/ajg.2011.155. Epub 2011 May 17. Am J Gastroenterol. 2011. PMID: 21577242
-
Risk of hepatocellular carcinoma in diabetic patients and risk reduction associated with anti-diabetic therapy: a population-based cohort study.Am J Gastroenterol. 2012 Jan;107(1):46-52. doi: 10.1038/ajg.2011.384. Epub 2011 Nov 15. Am J Gastroenterol. 2012. PMID: 22085817
-
Myocardial infarction and other co-morbidities in patients with chronic obstructive pulmonary disease: a Danish nationwide study of 7.4 million individuals.Eur Heart J. 2011 Oct;32(19):2365-75. doi: 10.1093/eurheartj/ehr338. Epub 2011 Aug 29. Eur Heart J. 2011. PMID: 21875856
-
Lung cancer in lung transplant recipients: experience of a tertiary hospital and literature review.Lung Cancer. 2011 Nov;74(2):280-3. doi: 10.1016/j.lungcan.2011.02.012. Epub 2011 May 6. Lung Cancer. 2011. PMID: 21529983 Review.
-
Diabetes mellitus is associated with breast cancer: systematic review, meta-analysis, and in silico reproduction.Panminerva Med. 2015 Sep;57(3):101-8. Panminerva Med. 2015. PMID: 25971328 Review.
Cited by
-
CARING (CAncer Risk and INsulin analoGues): the association of diabetes mellitus and cancer risk with focus on possible determinants - a systematic review and a meta-analysis.Curr Drug Saf. 2013 Nov;8(5):296-332. doi: 10.2174/15748863113086660071. Curr Drug Saf. 2013. PMID: 24215312 Free PMC article. Review.
-
Association between diabetes or antidiabetic therapy and lung cancer: A meta-analysis.J Diabetes Investig. 2013 Nov 27;4(6):659-66. doi: 10.1111/jdi.12112. Epub 2013 Jul 15. J Diabetes Investig. 2013. PMID: 24843722 Free PMC article.
-
Association between metformin use and progression of monoclonal gammopathy of undetermined significance to multiple myeloma in US veterans with diabetes mellitus: a population-based retrospective cohort study.Lancet Haematol. 2015 Jan;2(1):e30-6. doi: 10.1016/S2352-3026(14)00037-4. Lancet Haematol. 2015. PMID: 26034780 Free PMC article.
-
Associations between Diabetes Mellitus and Selected Cancers.Int J Mol Sci. 2024 Jul 8;25(13):7476. doi: 10.3390/ijms25137476. Int J Mol Sci. 2024. PMID: 39000583 Free PMC article. Review.
-
A short-term effect of low-dose aspirin on major hemorrhagic risks in primary prevention: a case-crossover design.PLoS One. 2014 May 30;9(5):e98326. doi: 10.1371/journal.pone.0098326. eCollection 2014. PLoS One. 2014. PMID: 24879431 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical