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Review
. 2011 Nov 17;11(12):865-78.
doi: 10.1038/nrc3143.

Gastrointestinal stromal tumours: origin and molecular oncology

Christopher L Corless  1 , Christine M Barnett, Michael C Heinrich
Affiliations
Review

Gastrointestinal stromal tumours: origin and molecular oncology

Christopher L Corless et al. Nat Rev Cancer. .

Abstract

Gastrointestinal stromal tumours (GISTs) are a paradigm for the development of personalized treatment for cancer patients. The nearly simultaneous discovery of a biomarker that is reflective of their origin and the presence of gain-of-function kinase mutations in these tumours set the stage for more accurate diagnosis and the development of kinase inhibitor therapy. Subsequent studies of genotype and phenotype have led to a molecular classification of GIST and to treatment optimization on the basis of molecular subtype. The study of drug-resistant tumours has advanced our understanding of kinase biology, enabling the development of novel kinase inhibitors. Further improvements in GIST treatment may require targeting GIST stem cell populations and/or additional genomic events.

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