Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2011:11:e40.
Epub 2011 Nov 3.

Complications following expander/implant breast reconstruction utilizing acellular dermal matrix: a systematic review and meta-analysis

Ian C Hoppe  1 , Janet H Yueh, Cindy H Wei, Naveen K Ahuja, Priti P Patel, Ramazi O Datiashvili
Affiliations

Complications following expander/implant breast reconstruction utilizing acellular dermal matrix: a systematic review and meta-analysis

Ian C Hoppe et al. Eplasty. 2011.

Abstract

Background: The recent increase in popularity of acellular dermal matrix assistance in immediate expander/implant breast reconstruction has led to variety of viewpoints. Many studies are published indicating an increase in complications with the use of acellular dermal matrix, while others indicate there is no increase in complications.

Methods: This meta-analysis utilizes information from available studies that directly compare one specific type of acellular dermal matrix with traditional methods of immediate expander/implant breast reconstruction. Eight studies were found through a meticulous literature search that met these criteria.

Results: There was more than a 2-fold increase in the number of infections and explanations in the acellular dermal matrix group compared to the control. There was a 3-fold increase in seroma formation in the acellular dermal matrix group compared to the control. There was a significant difference of intraoperative fill volumes between the acellular dermal matrix group compared to the control.

Conclusions: This study illustrates that after pooling all available date regarding the use of acellular dermal matrix in immediate expander/implant breast reconstruction there appears to be an increased rate of complications. However, the increased intraoperative fill volume may lead to ultimately greater patient satisfaction.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Study acquisition.
Figure 2
Figure 2
Forest plot of rate of infections between groups. ADM indicates acellular dermal matrix.
Figure 3
Figure 3
Forest plot of rate of seromas between groups. ADM indicates acellular dermal matrix.
Figure 4
Figure 4
Forest plot of rate of explantations between groups. ADM indicates acellular dermal matrix.
Figure 5
Figure 5
Forest plot of mean intraoperative tissue expander fill volume. Mean standard deviation from the other studies were used if no standard deviation was provided. ADM indicates acellular dermal matrix.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Breuing KH, Warren SM. Immediate bilateral breast reconstruction with implants and inferolateral AlloDerm slings. Ann Plast Surg. 2005;55(3):232–9. - PubMed
    1. Sbitany H, Sandeen SN, Amalfi AN, Davenport MS, Langstein HN. Acellular dermis-assisted prosthetic breast reconstruction versus complete submuscular coverage: a head-to-head comparison of outcomes. Plast Reconstr Surg. 2009;124(6):1735–40. - PubMed
    1. Chun YS, Verma K, Rosen H, et al. Implant-based breast reconstruction using acellular dermal matrix and the risk of postoperative complications. Plast Reconstr Surg. 2010;125(2):429–36. - PubMed
    1. Lanier ST, Wang ED, Chen JJ, et al. The effect of acellular dermal matrix use on complication rates in tissue expander/implant breast reconstruction. Ann Plast Surg. 2010;64(5):674–78. - PubMed
    1. Nguyen MD, Chen C, Colakoglu S, Morris DJ, Tobias AM, Lee BT. Infectious complications leading to explantation in implant-based breast reconstruction with AlloDerm. Eplasty. 2010;10:e48. - PMC - PubMed

LinkOut - more resources